🟢 95/100

This product looks safe

  • Piper methysticum Root Extract Concentrate, Dry: 400mg is 1.6× the Tolerable Upper Intake Level (250mg)
  • 43% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Piper methysticum Root Extract Concentrate, Dry: 400mg is 1.6× the Tolerable Upper Intake Level (250mg)

Label Data

2 Tablet(s) Serving Size
30 Servings
Botanical with Nutrients Product Type
43% Evidence Coverage

Supplement Facts — Evidence Check

⚠️ Exceeds Tolerable Upper Intake Level by 1.6× (UL: 250 mg) 📚 12 studies (Tier A: 0, B: 5)
This product: 400mg UL 250mg
Ziziphus jujuba var. spinosa Seed Extract Concentrate, Dry
300 mg
📊 Market median: 250.0mg (60 products) 📚 7 studies (Tier A: 0, B: 1)
This product: 75mg
Magnolia officinalis Stem Bark Extract Concentrate, Dry
150 mg
Melissa officinalis Leaf Extract Concentrate, Dry
75 mg
50 mg
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 50mg
Glycine
100 mg

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (74% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating)

Product Information

📋 Directions for Use

Adults Dose: Take 2 tablets once or twice daily.

⚠️ Warnings & Precautions

For practitioner dispensing only

Keep out of reach of children

Warning: Large tablet. Swallow with a glass of water. Not for prolonged use. May harm the liver. Mineral and nutrient supplements should not replace a balanced diet. If symptoms persist, talk to your health professional. Do not use if tamper evidence seal is broken. Bottle sealed under cap for your protection.

Not recommended for use by pregnant or lactating women.

🧪 Formulation Notes

Traditional mild anxiety and sleeplessness

Indication: Contains Kava which is traditionally used in Pacific Island medicine as a clamative. Melissa and Passiflora are traditionally used in Western herbal medicine to relieve sleeplessness, symptoms of mild anxiety and support healthy sleeping patterns.

Proudly Australian owned

Additional Information

Aust L 457860

Store below 30 degrees C in a cool, dry place away from direct sunlight.

Product Details

UPC / SKU 9 319091 979784
DSLD Entry Date 2024-12-21
Product Type Botanical with Nutrients
Form Tablet or Pill
Brand Orthoplex
DSLD ID 327215
Data Updated 2026-04-11

Research Evidence

19 Research Sources
48 Avg Quality Score
8 Rct
5 Systematic Review
4 Meta Analysis
2 Clinical Trial
B Kava extract for treating anxiety
Meta Analysis The Cochrane database of systematic reviews 2003
B Kava for Generalized Anxiety Disorder: A Review of Current Evidence
Meta Analysis Journal of alternative and complementary medicine (New York, N.Y.) 2018
B Kava extract for treating anxiety
Systematic Review The Cochrane database of systematic reviews 2001
B Kava extract for treating anxiety
Systematic Review The Cochrane database of systematic reviews 2002
B The effectiveness and safety of Kava Kava for treating anxiety symptoms: A systematic review and analysis of randomized clinical trials
Systematic Review Complementary therapies in clinical practice 2018
C Kava for generalised anxiety disorder: A 16-week double-blind, randomised, placebo-controlled study
Rct The Australian and New Zealand journal of psychiatry 2020
C Kava and St. John's Wort: current evidence for use in mood and anxiety disorders
Systematic Review Journal of alternative and complementary medicine (New York, N.Y.) 2009
C Neuroimaging Insights: Kava's (Piper methysticum) Effect on Dorsal Anterior Cingulate Cortex GABA in Generalized Anxiety Disorder.
Rct Nutrients
C The risk-benefit profile of commonly used herbal therapies: Ginkgo, St. John's Wort, Ginseng, Echinacea, Saw Palmetto, and Kava
Meta Analysis Annals of internal medicine 2002
C Efficacy of kava extract for treating anxiety: systematic review and meta-analysis
Meta Analysis Journal of clinical psychopharmacology 2000
View all evidence for Kava →

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