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Niacinamide 500 mg

product on market Tablet or Pill 21st Century Safety: 80/100
80/100

This product is generally safe

  • Niacinamide: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)
  • 50% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Niacinamide is supported by moderate evidence for supporting skin health and metabolic function. Calcium is essential for bone density and nerve signaling, with strong clinical evidence for these roles. Overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacinamide: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)

Label

Product Label

Label for Niacinamide 500 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
110
Servings
Single Vitamin and Mineral
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

500 mg (3125% DV)
Exceeds UL by 14.3× (UL: 35 mg) 196 studies (A:5, B:63)
Calcium
160 mg (12% DV)

Other Ingredients

Cellulose Hydroxypropyl Methylcellulose Stearic Acid Gum Acacia Magnesium Silicate Magnesium Stearate Polyethylene Glycol Polysorbate Polyvinyl Alcohol Silicon Dioxide
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a vitamin supplement, adults take one (1) tablet daily with any meal or as directed by a healthcare provider.

Warnings & Precautions

Do not exceed recommended dosage. Individual results may vary. Stop use and contact a physician if adverse reactions occur. Do not use if product appears to be tampered with or seal is broken.

Warning: Consult a healthcare provider prior to use if pregnant, nursing, on medications, have a medical condition or are planning a medical procedure.

Keep out of reach of children.

Formulation Notes

Prolonged release Energy & circulatory support Prolonged release vitamins slowly release nutrients into the body over an extended period of time.

Gluten free Non-GMO

Niacin (Vitamin B-3) plays a role in energy metabolism. Niacinamide is a good source of Vitamin B-3 with a lower flushing effect than that of niacin.

No added sugar, salt, yeast, preservatives, artificial flavors or colors.

Suitable for vegans.

Guaranteed quality Laboratory tested Trusted Quality For Over 30 Years

Additional Information

Store at room temperature.

Metadata

Product Details

UPC / SKU7 40985 22550 9
DSLD Entry Date2025-03-25
Product TypeSingle Vitamin and Mineral
FormTablet or Pill
Brand21st Century
DSLD ID326336
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
View all evidence for Niacin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.