🟡 60/100

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  • Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
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Safety Alerts

⚠️ Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)

This product received a low score because its 500mg dose of niacin is more than 14 times higher than the recommended maximum daily limit of 35mg.

Label Data

1 Tablet(s) Serving Size
120 Servings
Vitamin Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

500 mg (3125% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 14.3× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 500mg UL 35mg

Other Ingredients

Hypromellose Microcrystalline Cellulose Stearic Acid Vegetarian Coating Silica

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: Take one tablet with a meal 1-2 times per day or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Caution: Temporary flushing, itching or warming of the skin may occur.

Do not use if you have gout, diabetes, liver dysfunction or are pregnant.

Keep out of reach of children.

🧪 Formulation Notes

Niacin SR is NuMedica's sustained release niacin which features an advanced carnauba wax coating designed to release part of the niacin quickly with the remainder being released over a period of several hours with little or no flushing. Niacin has been found to support blood lipid levels related to healthy cardiovascular function by reducing the production of LDL and VLDL in the liver and increasing the production of beneficial HDL which draws cholesterol away from the lining of the arteries. Niacin also removes triglycerides from the blood through a process called "lipoprotein lipase activity" and appears to have a strong effect on the production of prostaglandins. Additionally, niacin dilates the blood vessels, improving circulation and may aid in flushing out existing plaque.

This formula meets or exceeds cGMP Quality Standards.

Sustained Release Niacin

Bloop lipid - circulation health

Does Not Contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy. GF Gluten-free

Vegetarian

Additional Information

Storage: Keep tightly closed in a cool, dry place.

Product Details

UPC / SKU 8 12527 01144 1
DSLD Entry Date 2024-12-21
Product Type Vitamin
Form Tablet or Pill
Brand NuMedica
DSLD ID 323626
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
View all evidence for Niacin →

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