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Niacin SR

product on market Tablet or Pill NuMedica Safety: 60/100
60/100

Review before taking

  • Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Niacin is used to manage lipid levels, with strong evidence supporting its role in raising HDL cholesterol. However, the limited evidence coverage for this specific formulation and a safety score of 60 suggest potential concerns. Users should be aware of possible side effects such as flushing or liver enzyme elevations.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This product received a low safety score because it contains 500mg of Niacin, which is over 14 times the recommended upper limit for daily intake.

Label

Product Label

Label for Niacin SR
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
120
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

500 mg (3125% DV)
Exceeds UL by 14.3× (UL: 35 mg) 196 studies (A:5, B:63)

Other Ingredients

Hypromellose Microcrystalline Cellulose Stearic Acid Vegetarian Coating Silica
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take one tablet with a meal 1-2 times per day or as directed by your healthcare practitioner.

Warnings & Precautions

Caution: Temporary flushing, itching or warming of the skin may occur.

Do not use if you have gout, diabetes, liver dysfunction or are pregnant.

Keep out of reach of children.

Formulation Notes

Niacin SR is NuMedica's sustained release niacin which features an advanced carnauba wax coating designed to release part of the niacin quickly with the remainder being released over a period of several hours with little or no flushing. Niacin has been found to support blood lipid levels related to healthy cardiovascular function by reducing the production of LDL and VLDL in the liver and increasing the production of beneficial HDL which draws cholesterol away from the lining of the arteries. Niacin also removes triglycerides from the blood through a process called "lipoprotein lipase activity" and appears to have a strong effect on the production of prostaglandins. Additionally, niacin dilates the blood vessels, improving circulation and may aid in flushing out existing plaque.

This formula meets or exceeds cGMP Quality Standards.

Sustained Release Niacin

Bloop lipid - circulation health

Does Not Contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy. GF Gluten-free

Vegetarian

Additional Information

Storage: Keep tightly closed in a cool, dry place.

Metadata

Product Details

UPC / SKU8 12527 01144 1
DSLD Entry Date2024-12-21
Product TypeVitamin
FormTablet or Pill
BrandNuMedica
DSLD ID323626
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
View all evidence for Niacin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.