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5-HTP 50 mg

product on market Capsule H&B Holland & Barrett Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 75% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Griffonia seed extract provides 5-HTP, which is supported by moderate evidence for mood regulation. Niacin, Vitamin B6, and magnesium serve as cofactors in neurotransmitter synthesis. Overall evidence coverage for this specific combination is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP 50 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
120
Servings
Botanical with Nutrients
Product Type
75%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

5 mg NE (31% DV)
Within RDA (0.4× RDA) 196 studies (A:5, B:63)
5 mg (357% DV)
3.8× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
25 mg (7% DV)
Within RDA (0.1× RDA) 316 studies (A:8, B:159)
Griffonia seed extract
250 mg

Other Ingredients

Griffonia seed extract Hydroxypropyl Methylcellulose Maltodextrin Magnesium Oxide Vitamin B6 Niacin Magnesium Stearate
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Info

Product Information

Directions for Use

Directions: Take 1-2 capsules per day, as needed or before bedtime.

1 a day

Warnings & Precautions

Do not exceed stated dose. Food supplements must not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Discontinue use and consult a doctor if adverse reactions occur. Do not use if seal under cap is broken or missing.

If you are pregnant, breastfeeding, taking any medications or under medical supervision, please consult a doctor or healthcare professional before use.

Keep out of sight and reach of children. This product is not intended for use by persons under the age of 18.

Formulation Notes

All our products are subject to our stringent quality assurance.

This product doesn't contain artificial flavours, colours or sweeteners.

Griffonia Simplicifolia Extract 250 mg Providing 20% 5-HTP 50 mg

Vegan

Additional Information

NRV = Nutrient Reference Value

I'm recycled plastic

Bottle made from at least 80% recycled plastic. Please recycle bottle with cap on.

Store in a cool, dry place.

Metadata

Product Details

DSLD Entry Date2025-01-23
Product TypeBotanical with Nutrients
FormCapsule
BrandH&B Holland & Barrett
DSLD ID321884
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.