Nitric Oxide MD +BioPerine by Approved Science — Ingredients, Evidence & Safety

🟢 100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
17% of ingredients have research evidence

B Label Compliance Grade

Product Label

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Label Data

3 Capsule(s) Serving Size

30 Servings

Other Combinations Product Type

17% Evidence Coverage

Supplement Facts — Evidence Check

Nitri-Sci L-Arginine Blend

1680 mg

📊 Market median: 500.0mg (143 products)

This product: 1680mg

L-Citrulline

480 mg

📊 Market median: 2000.0mg (275 products)

Median 2000.0mg This product: 480mg

Pine Bark Extract

30 mg

Quercetin

30 mg

📊 Market median: 500.0mg (283 products) 📚 173 studies (Tier A: 0, B: 62)

This product: 30mg

Longjack extract

30 mg

BioPerine

5 mg

Other Ingredients

Cellulose

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (97% of products) Structure/Function (91% of products) Nutrient (29% of products) No Claim (2% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Dairy Free

Product Information

📋 Directions for Use

Directions: On workout days: Take 3 capsules before breakfast and 3 capsules, 30 minutes before a workout with an 8 oz. glass of water. On rest days: Take 3 capsules before breakfast and 3 capsules before dinner with an 8 oz. glass of water.

⚠️ Warnings & Precautions

Caution: Do not exceed recommended dose. Do not use if safety seal is damaged or missing.

Pregnant women or nursing mothers, children under 18, and individuals with a known medical condition, should consult with a physician before taking this or any other dietary supplement.

Pregnant women or nursing mothers, children under 18, and individuals with a known medical condition, should consult with a physician before taking this or any other dietary supplement. Keep out of reach of children.

🧪 Formulation Notes

Manufactured in the USA according to current Good Manufacturing Practice (cGMP) and conforms to the tested ingredient grade, strength and purity of industry Quality Standards.

Vegan friendly

Made with GMO free ingredients

Advanced health support Premium grade High potency Safe Fast Natural formula Optimal strength GMP Certified

Contains Nitri-Sci 1680mg L-arginine Blend

100% vegan friendly

Additional Information

Vegan friendly Made in USA No animal testing GMP Good Manufacturing Practice Quality Product

Product Details

UPC / SKU X00287O8LL

DSLD Entry Date 2024-11-22

Product Type Other Combinations

Form Capsule

Brand Approved Science

DSLD ID 319800

Data Updated 2026-04-11

Research Evidence

12 Research Sources

45 Avg Quality Score

6 Rct

5 Clinical Trial

1 Meta Analysis

C Effect of food sources of nitrate, polyphenols, L-arginine and L-citrulline on endurance exercise performance: a systematic review and meta-analysis of randomised controlled trials

Meta Analysis Journal of the International Society of Sports Nutrition 2021

PubMed DOI

C Effects of L-Citrulline Supplementation on Endothelial Function and Blood Pressure in Hypertensive Postmenopausal Women.

Rct Nutrients

PubMed DOI

C Effects of Acute Citrulline Malate Supplementation on CrossFit® Exercise Performance: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Study.

Rct Nutrients

PubMed DOI

C Impact of L-Citrulline Supplementation and HIIT on Lipid Profile, Arterial Stiffness, and Fat Mass in Obese Adolescents with Metabolic-Dysfunction-Associated Fatty Liver Disease: A Randomized Clinical Trial.

Rct Nutrients

PubMed DOI

C Effect of L-Citrulline Supplementation on NAFLD in Adolescents With Obesity

Clinical Trial ClinicalTrials.gov 2021

ClinicalTrials.gov

C Effects of L-Citrulline or Citrulline-malate on Neuromuscular Performance in Resistance-trained Adults

Clinical Trial ClinicalTrials.gov 2022

ClinicalTrials.gov

C Acute effects of Nitrosigine® and citrulline malate on vasodilation in young adults.

Rct Journal of the International Society of Sports Nutrition

PubMed DOI

C Effects of Combined Versus Single Supplementation of Creatine, Beta-Alanine, and L-Citrulline During Short Sprint Interval Training on Basketball Players' Performance: A Double-Blind Randomized Placebo-Controlled Trial.

Rct International journal of sports physiology and performance

PubMed DOI

C Acute effects of combined supplementation of L-arginine and citrulline malate on aerobic, anaerobic, and CrossFit exercise performance.

Rct Scientific reports

PubMed DOI

C L-Citrulline in Peripheral Artery Disease

Clinical Trial ClinicalTrials.gov 2016

ClinicalTrials.gov

View all evidence for Citrulline →