🟡 60/100

Review before taking

  • Folate: 1667mg is 1667.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 1667mg is 1667.0× the Tolerable Upper Intake Level (1.0mg)

This product received a low safety score because the amount of folate it contains significantly exceeds the recommended maximum daily limit.

Label Data

1 Tablet(s) Serving Size
240 Servings
Vitamin Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

1667 mcg DFE (417% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1667.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 1667mg UL 1.0mg

Other Ingredients

Dicalcium Phosphate Microcrystalline Cellulose Stearic Acid Croscarmellose Sodium Magnesium Stearate Silicon Dioxide

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (77% of products) Nutrient (60% of products) Approved Health (5% of products)

Target Groups

Vegan Vegetarian Pregnant Women Adult Female (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested Use: Take one (1) tablet daily, preferably with food.

⚠️ Warnings & Precautions

Warning: Consult your doctor if you are pregnant, nursing, taking any medications or have a medical condition.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

🧪 Formulation Notes

Folic Acid is an essential B vitamin that supports the heart.

In addition, women who consume healthful diets with adequate folic acid may reduce their risk of having a child with birth defects of the brain or spinal cord.

No: Milk, egg, fish, crustacean shellfish, tree nuts, peanuts, yeast.

Made in U.S.A.

Vegan

Non GMO Gluten free

Prenatal support

Essential B-vitamin

Supports nervous system function

Additional Information

Store at room temperature.

Product Details

UPC / SKU 3 71309 58024 2
DSLD Entry Date 2024-09-25
Product Type Vitamin
Form Tablet or Pill
Brand Safrel
DSLD ID 318380
Data Updated 2026-04-11

Research Evidence

363 Research Sources
57 Avg Quality Score
187 Meta Analysis
56 Systematic Review
54 Rct
29 Guideline
26 Clinical Trial
6 Cochrane Review
2 Regulatory Source
1 Other
1 Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025
View all evidence for Folate →

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