Home/ Supplements/ Grape Seed/ OPC-3 (Oligomeric Proanthocyanidins)

OPC-3 (Oligomeric Proanthocyanidins)

product on market Powder Isotonix Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 25% of ingredients have research evidence
B Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

Grape seed and red wine extracts provide oligomeric proanthocyanidins, which have moderate evidence for supporting antioxidant activity and cardiovascular health. These ingredients may help neutralize free radicals and support blood vessel function. Evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for OPC-3 (Oligomeric Proanthocyanidins)
Open Full PDF View on NIH DSLD →
Details

Label Data

3.3 Gram(s)
Serving Size
90
Servings
Other Combinations
Product Type
25%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
10 Calorie(s)
Total Carbohydrates
2 Gram(s) (1% DV)
Potassium
95 mg (2% DV)
Market median: 100.0mg (284 products) 10 studies (A:0, B:4)
Red Wine extract
25 mg
Pycnogenol
25 mg
Market median: 100.0mg (120 products)
Market median: 500.0mg (283 products) 174 studies (A:0, B:62)

Other Ingredients

Fructose Glucose Citric Acid Maltodextrin Silica Calcium Sulfate Food Starch, Modified Apple Pectin Stearic Acid
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions for use: Pour 1 level, white bottle capful of powder into the overcap. Add water to the line on the overcap (2 fl oz/60 ml) and stir. As a dietary supplement, take once daily or as directed by your healthcare provider. Take 2 servings per 150 pounds of body weight daily for the first 7-10 days, and take 1 servings thereafter as a maintenance program. Maximum absorption occurs when taken on an empty stomach. This product is isotonic only if the specified amounts of powder and water are used.

Warnings & Precautions

Warning: If you are currently using prescription drugs, have an ongoing medical condition, or if you are pregnant or breastfeeding, consult your healthcare provider before using this product.

Keep out of the reach of children.

Do not use if safety seal is broken. Resale on third-party websites is strictly prohibited unless specifically authorized by Market America or its corporate affiliates. If barcodes are altered or you purchase this product from an unauthorized third-party website, the product is not guaranteed by Market America or its corporate affiliates.

Formulation Notes

Powerful antioxidant Promotes cardiovascular and joint health Helps maintain normal cholesterol and blood glucose levels Supports normal blood vessel function

Pycnogenol Nature's super antioxidants

This vegan product contains no added wheat, soy, yeast, gluten, artificial flavor, salt, preservatives or milk.

Gluten free

Vegan

Additional Information

Store in a cool, dry place.

Metadata

Product Details

UPC / SKU8 48570 00374 4
DSLD Entry Date2024-06-20
Product TypeOther Combinations
FormPowder
DSLD ID313409
Data Updated2026-04-11
Research

Research Evidence

14
Research Sources
50
Avg Quality
9
Rct
2
Meta Analysis
2
Clinical Trial
1
Systematic Review
B Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipidemia: A Multicenter, Randomized Controlled Trial
Rct Nutrients 2023 PubMed DOI
B Efficacy of Bilberry and Grape Seed Extract Supplement Interventions to Improve Glucose and Cholesterol Metabolism and Blood Pressure in Different Populations-A Systematic Review of the Literature
Systematic Review Nutrients 2021 PubMed DOI
B The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trials
Meta Analysis Journal of the American Dietetic Association 2011 PubMed DOI
B The impact of grape seed extract treatment on blood pressure changes: A meta-analysis of 16 randomized controlled trials
Meta Analysis Medicine 2016 PubMed DOI
B Grape Seed Extract Positively Modulates Blood Pressure and Perceived Stress: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Volunteers
Rct Nutrients 2021 PubMed DOI
C Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial
Rct The British journal of nutrition 2016 PubMed DOI
C Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome
Rct Metabolism: clinical and experimental 2009 PubMed DOI
C Grape seed extract supplementation along with a restricted-calorie diet improves cardiovascular risk factors in obese or overweight adult individuals: A randomized, placebo-controlled trial
Rct Phytotherapy research : PTR 2021 PubMed DOI
C The effect of polyphenol-rich chardonnay seed supplements on peripheral endothelial function.
Rct European journal of nutrition PubMed DOI
C The effects of grape seed extract supplementation on cardiovascular risk factors, liver enzymes and hepatic steatosis in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled study.
Rct BMC complementary medicine and therapies PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.