🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 33% of ingredients have research evidence
A Label Compliance Grade

Product Label

📸

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Label Data

2 Caplet(s) Serving Size
37 Servings
Other Combinations Product Type
33% Evidence Coverage

Supplement Facts — Evidence Check

Calories
10 {Calories}
Total Carbohydrates
2 Gram(s) (1% DV)
80 mcg (100% DV)
✅ Within RDA (0.7× RDA of 0.12 mg) 📚 273 studies (Tier A: 9, B: 175)
RDA 0.12mg This product: 0.08mg
Sodium
20 mg (1% DV)
1500 mg
📊 Market median: 1000.0mg (1115 products) 📚 22 studies (Tier A: 0, B: 9)
This product: 1500mg
Joint Shield(TM) Proprietary Blend
375 mg

Other Ingredients

Cellulose Crospovidone Contains Less Than 2% of

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (100% of products) Structure/Function (84% of products) Nutrient (73% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

DIRECTIONS FOR ADULT USE: TAKE TWO (2) CAPLETS PER DAY PREFERABLY WITH FOOD.

⚠️ Warnings & Precautions

CAUTION: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18.

TAMPER RESISTANT: DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.

Contains milk, soy and shellfish (shrimp, lobster, crab, crayfish) ingredients.

KEEP OUT OF REACH OF CHILDREN.

🧪 Formulation Notes

It contains 1,500 mg of Glucosamine, a key building block of cartilage.* With the addition of our Joint Shield(TM) Proprietary Blend which contains Chondroitin, MSM and our exclusive 5-LOXIN(R) Advanced, this revolutionary Bone Formula helps maintain bone mass and strength and revitalize your joints to keep them jumpin.*

5-LOXIN(R) Advanced contains high concentrations of AKBA, which is important for helping with joint flare-ups.*

GLUCOSAMINE CHONDROITIN

Free of Gluten

Contains milk, soy and shellfish (shrimp, lobster, crab, crayfish) ingredients.

Additional Information

As a reminder, discuss the supplements and medications you take with your health care providers.

PROUD SPONSOR of the ARTHRITIS FOUNDATION(R) Rexall Sundown, Inc., the maker of Osteo Bi-Flex(R), is proud to support the Arthritis Foundation’s efforts to help people take control of arthritis. For information about arthritis, contact the Foundation at 1-800-568-4045 or www.arthritis.org

52876 00A B52876 MAB

Osteo Bi-Flex(R) helps revitalize your joints to keep them jumpin’.* The natural aging process can add excessive stress on your joints. Annoying flare-ups can strike at any time. Add Osteo Bi-Flex(R) Joint & Bone to your joint care regimen.

Starts working to improve joint comfort within 7 days.*#

#Based on two human studies with 5-LOXIN(R) Advanced where subjects rated their joint health over time, subjects’ joint health improved within 7 days, and continued to improve throughout the duration of the studies.

Part No. 22-52876

Proud sponsor of the ARTHRITIS FOUNDATION(R)

MAINTAIN BONE MASS & STRENGTH* HELPS REVITALIZE YOUR JOINTS* KEY BUILDING BLOCK OF CARTILAGE*

2 PER DAY

Osteo Bi-Flex(R) is manufactured under the highest standards for product quality, purity and potency.

**52 Week Nielsen ScanTrack data ending 11/24/12.

STORE AT ROOM TEMPERATURE AND AVOID EXCESSIVE HEAT.

Product Details

UPC / SKU 0 30768 52876 8
DSLD Entry Date 2014-02-26
Product Type Other Combinations
Form Other (e.g. tea bag)
DSLD ID 30802
Data Updated 2026-04-11

Research Evidence

332 Research Sources
59 Avg Quality Score
220 Meta Analysis
56 Systematic Review
30 Rct
16 Clinical Trial
3 Guideline
3 Regulatory Source
1 Narrative Review
1 Other
1 Openfda Safety
A Duration of treatment with vitamin K antagonists in symptomatic venous thromboembolism
Meta Analysis The Cochrane database of systematic reviews 2014
A Antiplatelet and anticoagulant agents for secondary prevention of stroke and other thromboembolic events in people with antiphospholipid syndrome
Meta Analysis The Cochrane database of systematic reviews 2017
A Anticoagulants (extended duration) for prevention of venous thromboembolism following total hip or knee replacement or hip fracture repair
Meta Analysis The Cochrane database of systematic reviews 2016
A Antiplatelet and anticoagulant agents for secondary prevention of stroke and other thromboembolic events in people with antiphospholipid syndrome
Meta Analysis The Cochrane database of systematic reviews 2020
A Direct factor Xa inhibitors versus low molecular weight heparins or vitamin K antagonists for prevention of venous thromboembolism in elective primary hip or knee replacement or hip fracture repair
Meta Analysis The Cochrane database of systematic reviews 2025
A Factor Xa inhibitors versus vitamin K antagonists for preventing cerebral or systemic embolism in patients with atrial fibrillation
Meta Analysis The Cochrane database of systematic reviews 2018
A Antiplatelet agents and anticoagulants for hypertension
Systematic Review The Cochrane database of systematic reviews 2022
A Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy
Meta Analysis The Cochrane database of systematic reviews 2012
A Factor Xa inhibitors versus vitamin K antagonists for preventing cerebral or systemic embolism in patients with atrial fibrillation
Meta Analysis The Cochrane database of systematic reviews 2013
A Anticoagulation for the long-term treatment of venous thromboembolism in patients with cancer
Meta Analysis The Cochrane database of systematic reviews 2014
View all evidence for Vitamin K →

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