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Osteo Bi-Flex Joint & Bone

product on market Other (e.g. tea bag) Osteo Bi-Flex Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 33% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

Glucosamine HCl is supported by moderate evidence for supporting joint health and cartilage maintenance. Vitamin K plays a role in bone mineralization and calcium regulation. These ingredients are generally recognized as safe for use in the general population.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Osteo Bi-Flex Joint & Bone
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Caplet(s)
Serving Size
37
Servings
Other Combinations
Product Type
33%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
10 {Calories}
Total Carbohydrates
2 Gram(s) (1% DV)
80 mcg (100% DV)
Within RDA (0.7× RDA) 275 studies (A:9, B:175)
Sodium
20 mg (1% DV)
1500 mg
Market median: 1000.0mg (1115 products) 24 studies (A:0, B:9)
Joint Shield(TM) Proprietary Blend
375 mg

Other Ingredients

Cellulose Crospovidone Contains Less Than 2% of
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

DIRECTIONS FOR ADULT USE: TAKE TWO (2) CAPLETS PER DAY PREFERABLY WITH FOOD.

Warnings & Precautions

CAUTION: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18.

TAMPER RESISTANT: DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.

Contains milk, soy and shellfish (shrimp, lobster, crab, crayfish) ingredients.

KEEP OUT OF REACH OF CHILDREN.

Formulation Notes

It contains 1,500 mg of Glucosamine, a key building block of cartilage.* With the addition of our Joint Shield(TM) Proprietary Blend which contains Chondroitin, MSM and our exclusive 5-LOXIN(R) Advanced, this revolutionary Bone Formula helps maintain bone mass and strength and revitalize your joints to keep them jumpin.*

5-LOXIN(R) Advanced contains high concentrations of AKBA, which is important for helping with joint flare-ups.*

GLUCOSAMINE CHONDROITIN

Free of Gluten

Contains milk, soy and shellfish (shrimp, lobster, crab, crayfish) ingredients.

Additional Information

As a reminder, discuss the supplements and medications you take with your health care providers.

PROUD SPONSOR of the ARTHRITIS FOUNDATION(R) Rexall Sundown, Inc., the maker of Osteo Bi-Flex(R), is proud to support the Arthritis Foundation’s efforts to help people take control of arthritis. For information about arthritis, contact the Foundation at 1-800-568-4045 or www.arthritis.org

52876 00A B52876 MAB

Osteo Bi-Flex(R) helps revitalize your joints to keep them jumpin’.* The natural aging process can add excessive stress on your joints. Annoying flare-ups can strike at any time. Add Osteo Bi-Flex(R) Joint & Bone to your joint care regimen.

Starts working to improve joint comfort within 7 days.*#

#Based on two human studies with 5-LOXIN(R) Advanced where subjects rated their joint health over time, subjects’ joint health improved within 7 days, and continued to improve throughout the duration of the studies.

Part No. 22-52876

Proud sponsor of the ARTHRITIS FOUNDATION(R)

MAINTAIN BONE MASS & STRENGTH* HELPS REVITALIZE YOUR JOINTS* KEY BUILDING BLOCK OF CARTILAGE*

2 PER DAY

Osteo Bi-Flex(R) is manufactured under the highest standards for product quality, purity and potency.

**52 Week Nielsen ScanTrack data ending 11/24/12.

STORE AT ROOM TEMPERATURE AND AVOID EXCESSIVE HEAT.

Metadata

Product Details

UPC / SKU0 30768 52876 8
DSLD Entry Date2014-02-26
Product TypeOther Combinations
FormOther (e.g. tea bag)
DSLD ID30802
Data Updated2026-04-11
Research

Research Evidence

332
Research Sources
59
Avg Quality
220
Meta Analysis
56
Systematic Review
30
Rct
16
Clinical Trial
3
Guideline
3
Regulatory Source
1
Narrative Review
1
Other
1
Openfda Safety
A Duration of treatment with vitamin K antagonists in symptomatic venous thromboembolism
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Antiplatelet and anticoagulant agents for secondary prevention of stroke and other thromboembolic events in people with antiphospholipid syndrome
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Anticoagulants (extended duration) for prevention of venous thromboembolism following total hip or knee replacement or hip fracture repair
Meta Analysis The Cochrane database of systematic reviews 2016 PubMed DOI
A Antiplatelet and anticoagulant agents for secondary prevention of stroke and other thromboembolic events in people with antiphospholipid syndrome
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Direct factor Xa inhibitors versus low molecular weight heparins or vitamin K antagonists for prevention of venous thromboembolism in elective primary hip or knee replacement or hip fracture repair
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
A Factor Xa inhibitors versus vitamin K antagonists for preventing cerebral or systemic embolism in patients with atrial fibrillation
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
A Antiplatelet agents and anticoagulants for hypertension
Systematic Review The Cochrane database of systematic reviews 2022 PubMed DOI
A Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy
Meta Analysis The Cochrane database of systematic reviews 2012 PubMed DOI
A Factor Xa inhibitors versus vitamin K antagonists for preventing cerebral or systemic embolism in patients with atrial fibrillation
Meta Analysis The Cochrane database of systematic reviews 2013 PubMed DOI
A Anticoagulation for the long-term treatment of venous thromboembolism in patients with cancer
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.