🟢 90/100

This product looks safe

  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 22% of ingredients have research evidence
B Label Compliance Grade

Product Label

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Safety Alerts

ℹ️ Contains proprietary blend — exact ingredient amounts not disclosed

Label Data

2 Tablet(s) Serving Size
60 Servings
Other Combinations Product Type
22% Evidence Coverage

Supplement Facts — Evidence Check

Calories
10 Calorie(s)
Total Carbohydrates
2 Gram(s) (1% DV)
Vitamin C
60 mg (67% DV)
2 mg (87% DV)
✅ Within RDA (0.9× RDA of 2.3 mg) 📚 8 studies — no high-quality reviews
RDA 2.3mg This product: 2mg UL 11mg
Sodium
50 mg (2% DV)
📊 Market median: 1000.0mg (1115 products) 📚 22 studies (Tier A: 0, B: 9)
This product: 1500mg
Proprietary Blend
1103 mg
📊 Market median: 375.0mg (171 products) 📚 30 studies (Tier A: 1, B: 14)
This product: 100mg
3 mg
📊 Market median: 3.0mg (58 products) 📚 2 studies — no high-quality reviews
This product: 3mg UL 20mg

Other Ingredients

Cellulose Polyplasdone FD&C Blue #2 Carmine FD&C Red #40 FD&C Yellow #5 Magnesium Silicate Magnesium Stearate Polyethylene Glycol Polyvinyl Alcohol Silicon Dioxide Stearic Acid Titanium Dioxide

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (100% of products) Structure/Function (89% of products) Nutrient (16% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Directions: As a dietary supplement, adults take two (2) tablets daily with any meal of as directed by a healthcare provider. Do not exceed recommended dosage. Individual results may vary.

2 per day

⚠️ Warnings & Precautions

Do not exceed recommended dosage.

Warning: Consult a healthcare provider prior to use if pregnant, nursing, taking medications, including blood thinners, have a medical condition or are planning a medical procedure.

Stop use and contact a physician if adverse reactions occur.

Keep out of reach of children.

Do not use if product appears to be tampered with or seal is broken.

Contains shellfish (shrimp, crab, lobster, crayfish).

🧪 Formulation Notes

Glucosamine Chondroitin Complex plus MSM Advanced Triple Strength combines Glucosamine Hydrochloride with complimentary nutrients that help support joints and cartilage.

No artificial flavors or preservatives.

Advanced Triple Strength

Additional Information

Store at room temperature.

Guaranteed quality Laboratory tested

Product Details

UPC / SKU 7 40985 27438 5
DSLD Entry Date 2023-12-14
Product Type Other Combinations
Form Tablet or Pill
Brand 21st Century
DSLD ID 304100
Data Updated 2026-04-11

Research Evidence

39 Research Sources
50 Avg Quality Score
20 Rct
9 Meta Analysis
4 Clinical Trial
3 Systematic Review
1 Regulatory Source
1 Openfda Safety
B Interventions for the management of temporomandibular joint osteoarthritis
Systematic Review The Cochrane database of systematic reviews 2012
B Glucosamine therapy for treating osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2005
B Chondroitin for osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2015
B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis
Meta Analysis Archives of orthopaedic and trauma surgery 2023
B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis
Rct The New England journal of medicine 2006
B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review
Systematic Review International journal of molecular sciences 2023
B Scientific Opinion on glucosamine and joint health
Regulatory Source EFSA Journal 2009
B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis
Meta Analysis Computational and mathematical methods in medicine 2022
B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
Rct Annals of the rheumatic diseases 2016
B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials
Meta Analysis Journal of orthopaedic surgery and research 2018
View all evidence for Glucosamine →

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