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Sustained-Release Niacin with niaXtend 500 mg

product on market Tablet or Pill Doctor's Best Safety: 60/100
60/100

Review before taking

  • Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Niacin is used to support healthy cholesterol levels, though evidence for its efficacy varies by specific health goal. Research provides moderate support for its role in lipid management. Due to a safety score of 60, potential concerns regarding flushing or liver enzyme elevation should be noted.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)

AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This product received a low safety score because it contains 500mg of Niacin, which is over 14 times the recommended upper limit for daily intake.

Label

Product Label

Label for Sustained-Release Niacin with niaXtend 500 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
120
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

500 mg (3125% DV)
Exceeds UL by 14.3× (UL: 35 mg) 196 studies (A:5, B:63)

Other Ingredients

Rice Bran Carnauba Wax Stearic Acid Magnesium Stearate Silica
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Adult Use: Take 1 tablet daily with food, or as recommended by a nutritionally informed physician.

Warnings & Precautions

Warning: If you are pregnant, nursing, have a medical condition, or taking medication, consult your physician before taking this product.

Temporary flushing such as warmth, itching or redness of the skin, are common side effects that may occur upon initial use. These effects may worsen if you drink alcohol or hot beverages shortly after taking niacin. Do not take more than 500 mg per day (one tablet) except under the supervision of a physician. Liver damage and jaundice are risks with high doses of niacin. Avoid high doses of niacin if you have a liver or kidney disorder.

Formulation Notes

Doctor's Best Sustained-Release Niacin with niaXtend provides niacin in a form that helps minimize the incidence of uncomfortable skin flushing that is commonly associated with niacin. Approximately 200 coenzymes are comprised of niacin that play pivotal roles in metabolism and energy production within the body. niaXtend has been tested to encourage a favorable blood lipid profile. Research suggests that niacin, in combination with a well-balanced diet, may help maintain healthy cholesterol levels that are already within the normal range.

Non-GMO / Gluten Free

Helps support cardiovascular health Low flush

Vegan

Helps support cardiovascular health Helps encourage a favorable balance of blood lipids Sustained-release formula decreases incidence of "skin flushing"

Additional Information

Store in a cool dry place.

Metadata

Product Details

UPC / SKU7 53950 00242 5
DSLD Entry Date2024-01-24
Product TypeVitamin
FormTablet or Pill
DSLD ID302710
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
View all evidence for Niacin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.