🟡 60/100

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  • Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
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Safety Alerts

⚠️ Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)

The safety score is low because the 500mg dose of niacin is more than 14 times higher than the recommended maximum daily limit of 35mg.

Label Data

1 Tablet(s) Serving Size
120 Servings
Vitamin Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

500 mg (3125% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 14.3× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 500mg UL 35mg

Other Ingredients

Rice Bran Carnauba Wax Stearic Acid Magnesium Stearate Silica

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested Adult Use: Take 1 tablet daily with food, or as recommended by a nutritionally informed physician.

⚠️ Warnings & Precautions

Warning: If you are pregnant, nursing, have a medical condition, or taking medication, consult your physician before taking this product.

Temporary flushing such as warmth, itching or redness of the skin, are common side effects that may occur upon initial use. These effects may worsen if you drink alcohol or hot beverages shortly after taking niacin. Do not take more than 500 mg per day (one tablet) except under the supervision of a physician. Liver damage and jaundice are risks with high doses of niacin. Avoid high doses of niacin if you have a liver or kidney disorder.

🧪 Formulation Notes

Doctor's Best Sustained-Release Niacin with niaXtend provides niacin in a form that helps minimize the incidence of uncomfortable skin flushing that is commonly associated with niacin. Approximately 200 coenzymes are comprised of niacin that play pivotal roles in metabolism and energy production within the body. niaXtend has been tested to encourage a favorable blood lipid profile. Research suggests that niacin, in combination with a well-balanced diet, may help maintain healthy cholesterol levels that are already within the normal range.

Non-GMO / Gluten Free

Helps support cardiovascular health Low flush

Vegan

Helps support cardiovascular health Helps encourage a favorable balance of blood lipids Sustained-release formula decreases incidence of "skin flushing"

Additional Information

Store in a cool dry place.

Product Details

UPC / SKU 7 53950 00242 5
DSLD Entry Date 2024-01-24
Product Type Vitamin
Form Tablet or Pill
DSLD ID 302710
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
View all evidence for Niacin →

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