🟡 60/100

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  • Niacin: 1000mg is 28.6× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
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Safety Alerts

⚠️ Niacin: 1000mg is 28.6× the Tolerable Upper Intake Level (35mg)

This product received a low score because its 1000mg dose of niacin is over 28 times higher than the recommended maximum daily limit of 35mg.

Label Data

1 Tablet(s) Serving Size
90 Servings
Vitamin Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

1000 mg NE (6250% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 28.6× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 1000mg UL 35mg

Other Ingredients

Stearic Acid Dicalcium Phosphate Hydroxypropyl Methylcellulose Magnesium Stearate Rice Bran Silica Pharmaceutical Glaze

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) No Allergies Gluten Free

Product Information

📋 Directions for Use

Directions: One tablet daily.

⚠️ Warnings & Precautions

Keep out of reach of children.

🧪 Formulation Notes

Niacinamide is the "non-flush" version of the nutrient Niacin (vitamin B3). It is key in hundreds of metabolic reactions. Every process in every cell of the human body relies on the energy-producing reactions of Niacin. It is used by the body or the synthesis of proteins and fatty acids as well as the formation of hormones and red blood cells. Most importantly, Niacin is an important regulator of white blood cells, needed for a strong immune response.

In special base which provides for the gradual release of ingredients over a prolonged period of time. Micro-gel sustained release system

Sustained release Heart Support

Intended for the correction of Niacin deficiency.

Vegetarian

Gluten Free

Free from artificial colors and artificial preservatives. Free from all the major allergens identified in the U.S. Food Allergen Labeling and Consumer Protection Act.

Additional Information

Keep tightly closed in a cool, dry place.

Product Details

UPC / SKU 0 97467 01930 0
DSLD Entry Date 2023-10-24
Product Type Vitamin
Form Tablet or Pill
Brand NaturesPlus
DSLD ID 298729
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
View all evidence for Niacin →

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