Advanced Therapeutics Glucosamine Chondroitin MSM Ultra Rx-Joint by NaturesPlus — Ingredients, Evidence & Safety

Product Label

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Safety Alerts

⚠️ Manganese: 20mg is 1.8× the Tolerable Upper Intake Level (11mg)

Label Data

3 Extended Delivery Tablet(s) Serving Size

60 Servings

Other Combinations Product Type

40% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin C

200 mg (222% DV)

Manganese

20 mg (870% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 1.8× (UL: 11 mg) 📚 8 studies — no high-quality reviews

RDA 2.3mg This product: 20mg UL 11mg

Glucosamine Sulfate

1000 mg

📊 Market median: 1000.0mg (1115 products) 📚 22 studies (Tier A: 0, B: 9)

This product: 1000mg

Methylsulfonyl Methane

1000 mg

📊 Market median: 1000.0mg (2 products)

This product: 1000mg

Chondroitin Sulfate

800 mg

📊 Market median: 600.0mg (79 products) 📚 24 studies (Tier A: 0, B: 6)

This product: 800mg

Other Ingredients

Hydroxypropyl Methylcellulose Stearic Acid Dicalcium Phosphate Magnesium Stearate Pharmaceutical Glaze

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (89% of products) Nutrient (16% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: As a dietary supplement, three tablets once daily.

⚠️ Warnings & Precautions

Free from allergens milk, eggs, fish, tree nuts, peanuts, wheat, and soy.

Keep out of reach of children.

🧪 Formulation Notes

Nutritional support for healthy joint function.

Advanced Therapeutics Glucosamine Chondroitin MSM Ultra Rx-Joint is a targeted, condition-specific formulation designed to nutritionally support healthy joint function.

Each triple-action tablet supplies the critical joint nutrients - glucosamine sulfate, chondroitin sulfate and methylsulfonylmethane (MSM) - for peak joint lubrication and mobility.

In a special base which provides for the gradual release of ingredients over a prolonged period of time.

Gluten Free

Extended Delivery

Triple Action with MSM OptiMSM Optimal Purity. Optimal Health.

Additional Information

Keep tightly closed in a cool, dry place.

Product Details

UPC / SKU 0 97467 04924 6

DSLD Entry Date 2023-10-24

Product Type Other Combinations

Form Tablet or Pill

Brand NaturesPlus

DSLD ID 298222

Data Updated 2026-04-11

Research Evidence

39 Research Sources

50 Avg Quality Score

20 Rct

9 Meta Analysis

4 Clinical Trial

3 Systematic Review

1 Regulatory Source

1 Openfda Safety

B Interventions for the management of temporomandibular joint osteoarthritis

Systematic Review The Cochrane database of systematic reviews 2012

PubMed DOI Cochrane

B Glucosamine therapy for treating osteoarthritis

Meta Analysis The Cochrane database of systematic reviews 2005

PubMed Cochrane

B Chondroitin for osteoarthritis

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI Cochrane

B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis

Meta Analysis Archives of orthopaedic and trauma surgery 2023

PubMed DOI

B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis

Rct The New England journal of medicine 2006

PubMed

B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review

Systematic Review International journal of molecular sciences 2023

PubMed DOI

B Scientific Opinion on glucosamine and joint health

Regulatory Source EFSA Journal 2009

DOI

B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis

Meta Analysis Computational and mathematical methods in medicine 2022

PubMed DOI

B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib

Rct Annals of the rheumatic diseases 2016

PubMed DOI

B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials

Meta Analysis Journal of orthopaedic surgery and research 2018

PubMed DOI

View all evidence for Glucosamine →