Advanced Therapeutics Glucosamine Chondroitin MSM Ultra Rx-Joint by NaturesPlus

92/100

This product looks safe

Manganese: 20mg is 1.8× the Tolerable Upper Intake Level (11mg)
40% of ingredients have research evidence

C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Glucosamine, chondroitin, and MSM are commonly used to support joint health, though clinical evidence for their efficacy remains limited and mixed. Vitamin C and manganese serve as essential cofactors for connective tissue synthesis. The overall evidence coverage for this specific combination is very low.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Manganese: 20mg is 1.8× the Tolerable Upper Intake Level (11mg)

Label

Product Label

Open Full PDF View on NIH DSLD →

Details

Label Data

3 Extended Delivery Tablet(s)

Serving Size

Servings

Other Combinations

Product Type

40%

Evidence Coverage

Ingredients

Supplement Facts — Evidence Check

Vitamin C

200 mg (222% DV)

Manganese

20 mg (870% DV)

Exceeds UL by 1.8× (UL: 11 mg) 9 studies — no high-quality reviews

Glucosamine Sulfate

1000 mg

Market median: 1000.0mg (1115 products) 24 studies (A:0, B:9)

Methylsulfonylmethane

1000 mg

Market median: 1000.0mg (2 products)

Chondroitin Sulfate

800 mg

Market median: 600.0mg (79 products) 25 studies (A:0, B:6)

Other Ingredients

Hydroxypropyl Methylcellulose Stearic Acid Dicalcium Phosphate Magnesium Stearate Pharmaceutical Glaze

Claims

Label Claims — Verification

Unverified Nutrient

Unverified All Other

Unverified Structure/Function

Info

Product Information

Directions for Use

Directions: As a dietary supplement, three tablets once daily.

Warnings & Precautions

Keep out of reach of children.

This is not a prescription product. It is a dietary supplement made with the highest possible quality standards.

Formulation Notes

Nutritional Support for Healthy Joint Function Advanced Therapeutics Glucosamine Chondroitin MSM Ultra Rx-Joint is a targeted, condition-specific formulation designed to nutritionally support healthy joint function. Each triple-action tablet supplies the critical joint nutrients - glucosamine sulfate, chondroitin sulfate and methylsufonylmethane (MSM) - for peak joint lubrication and mobility.

Free from artificial colors and artificial preservatives. Free from the allergens milk, eggs, fish, tree nuts, peanuts, wheat and soy.

In a special base which provides for the gradual release of ingredients over a prolonged period of time.

Gluten Free

Triple Action MSM Opti MSM Optimal Purity Optimal Health

Additional Information

Keep tightly closed in a cool, dry place.

Metadata

Product Details

UPC / SKU0 97467 04923 9

DSLD Entry Date2023-10-24

Product TypeOther Combinations

FormTablet or Pill

BrandNaturesPlus

DSLD ID298221

Data Updated2026-04-11

Research

Research Evidence

Research Sources

Avg Quality

Rct

Meta Analysis

Clinical Trial

Systematic Review

Regulatory Source

Openfda Safety

B Interventions for the management of temporomandibular joint osteoarthritis

Systematic Review The Cochrane database of systematic reviews 2012 PubMed DOI

B Glucosamine therapy for treating osteoarthritis

Meta Analysis The Cochrane database of systematic reviews 2005 PubMed

B Chondroitin for osteoarthritis

Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI

B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis

Meta Analysis Archives of orthopaedic and trauma surgery 2023 PubMed DOI

B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis

Rct The New England journal of medicine 2006 PubMed

B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review

Systematic Review International journal of molecular sciences 2023 PubMed DOI

B Scientific Opinion on glucosamine and joint health

Regulatory Source EFSA Journal 2009 DOI

B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis

Meta Analysis Computational and mathematical methods in medicine 2022 PubMed DOI

B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib

Rct Annals of the rheumatic diseases 2016 PubMed DOI

B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials

Meta Analysis Journal of orthopaedic surgery and research 2018 PubMed DOI

View all evidence for Glucosamine →

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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.