🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade

Product Label

📸

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Label Data

1 Capsule(s) Serving Size
60 Servings
Other Combinations Product Type
0% Evidence Coverage

Supplement Facts — Evidence Check

Protease Thera-Blend
Catalase
SOD/Gliadin Complex
40 mg
📊 Market median: 200.0mg (198 products) 📚 6 studies — no high-quality reviews
This product: 40mg
Glutathione
30 mg

Other Ingredients

100% Vegetarian Capsule

Label Claims — Verification

All Other
Structure/Function
All Other (98% of products) Structure/Function (87% of products) Nutrient (16% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Dairy Free

Product Information

📋 Directions for Use

Recommended usage: For maintenance: Take one capsule daily on an empty stomach. (1 hour before or 2 hours after a meal). For therapeutic use: Take two capsules twice daily on an empty stomach. More may be taken as needed.

⚠️ Warnings & Precautions

The Superoxide Dismutase (SOD) in this formula has been protected by a wheat protein called gliadin in order to bypass the acid environment of the stomach. Gliadin is a glycoprotein found in gluten, so individuals with gluten sensitivities may also be sensitive to gliadin.

Please consult with a physician before taking if you are pregnant or lactating.

Please keep out of reach of children

🧪 Formulation Notes

Absolutely no fillers added

With the addition of glutathione this formula represents one of the most potent antioxidants available.

Enzymedica uses an exclusive Thera-blend process for its protease, lipase, amylase and cellulase.

Vegetarian & Vegan

Super antioxidant with SOD & Glutathione

Contains no dairy, preservatives, salt, sucrose, soy, yeast, nuts, artificial colors or flavors.

Additional Information

Defenze contains a high potency blend of enzymes that have been studied for their antioxidant qualities. They have been proven to assist in reducing the damage caused by free radicals.

Each of these enzymes actually represents multiple strains that are blended to increase potency in varying pH levels.

The enzyme experts

Therapeutic Plant based enzymes

Antioxidant enzyme formula

Keep closed in dry place; do not expose to excessive heat

Made in USA

Product Details

UPC / SKU 6 70480 27060 8
DSLD Entry Date 2011-12-23
Product Type Other Combinations
Form Capsule
Brand Enzymedica
DSLD ID 2970
Data Updated 2026-04-11

Research Evidence

21 Research Sources
52 Avg Quality Score
13 Rct
4 Meta Analysis
2 Systematic Review
2 Clinical Trial
A Alpha-lipoic acid for diabetic peripheral neuropathy
Systematic Review The Cochrane database of systematic reviews 2024
B Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy
Rct Nutrients 2024
B Alpha Lipoic Acid Supplementation and Iron Homeostasis: A Comprehensive Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
Meta Analysis International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 2024
B Effectiveness of alpha-lipoic acid in patients with neuropathic pain associated with type I and type II diabetes mellitus: A systematic review and meta-analysis
Meta Analysis Medicine 2023
C The effects of alpha-lipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Metabolism: clinical and experimental 2018
C A systematic review and meta-analysis of α-lipoic acid in the treatment of diabetic peripheral neuropathy
Meta Analysis European journal of endocrinology 2012
C Oral Alpha Lipoic Acid Treatment for Symptomatic Diabetic Peripheral Neuropathy: A Randomized Double-Blinded Placebo-Controlled Study
Rct Endocrine, metabolic & immune disorders drug targets 2020
C A randomized, double-blind, placebo controlled study to evaluate the effect of alpha-lipoic acid on inhibition of ADP-and collagen-induced platelet aggregation ex vivo in diabetic neuropathy patients on gabapentin or pregabalin
Rct Journal of postgraduate medicine 2024
C Ranking Alpha Lipoic Acid and Gamma Linolenic Acid in Terms of Efficacy and Safety in the Management of Adults With Diabetic Peripheral Neuropathy: A Systematic Review and Network Meta-analysis
Systematic Review Canadian journal of diabetes 2024
C Effect analysis of tanshinone IIA sulfonate sodium combined with a-lipoic acid in patients with diabetes peripheral neuropathy.
Rct Pakistan journal of pharmaceutical sciences
View all evidence for Alpha Lipoic Acid →

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