Home/ Supplements/ Folate/ Meta-Sitosterol 2.0

Meta-Sitosterol 2.0

product on market Tablet or Pill Metagenics Safety: 94/100
94/100

This product looks safe

  • Folate: 445mg is 445.0× the Tolerable Upper Intake Level (1.0mg)
  • 17% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Beta-sitosterol, campesterol, and stigmasterol are plant sterols with moderate evidence for supporting healthy cholesterol levels by inhibiting dietary cholesterol absorption. Folate is a critical nutrient for cellular function and DNA synthesis. Overall, the evidence coverage for this specific ingredient combination is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 445mg is 445.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Meta-Sitosterol 2.0
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
90
Servings
Fat/Fatty Acid
Product Type
17%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Total Carbohydrates
445 mcg DFE (111% DV)
Exceeds UL by 445.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
Beta-Sitosterol
333 mg
Campesterol
167 mg
Stigmasterol
92 mg
Other Plant Sterols
117 mg

Other Ingredients

Plant Sterol Complex Microcrystalline Cellulose Croscarmellose Sodium Cellulose Stearic Acid Silica Calcium L-5-Methyltetrahydrofolate
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take one tablet with each meal or as directed by your healthcare practitioner.

Warnings & Precautions

Caution: Keep out of the reach of children.

Practitioner Exclusive

Contains: Soy.

Formulation Notes

Meta-Sitosterol 2.0 is a naturally derived vegetable preparation featuring enhanced levels of a balanced concentrate of plant sterols - 2 grams per day - which may help to maintain healthy blood levels already within the normal range. Also features the active, preferred form of folate (L-5-methyltetrahydrofolate) to support healthy homocysteine metabolism and cardiovascular health.

The National Institute of Health recommends a healthy diet, along with the consumption of 2 grams of plant sterols daily, to promote cardiovascular health.

This gluten-free and vegetarian.

This gluten-free and vegetarian.

Certified Gluten Free GFCO.org (Gluten-Free Certification Organization)

Plant sterol complex for support of healthy cholesterol levels

Additional Information

Do not refrigerate (Refrigeration may cause moisture condensation)

Certified Gluten Free GFCO.org (Gluten-Free Certification Organization)

Metadata

Product Details

UPC / SKU7 55571 91066 0
DSLD Entry Date2023-08-23
Product TypeFat/Fatty Acid
FormTablet or Pill
BrandMetagenics
DSLD ID295795
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
View all evidence for Folate →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.