Meta-Sitosterol 2.0 by Metagenics — Ingredients, Evidence & Safety

🟢 94/100

This product looks safe

Folate: 445mg is 445.0× the Tolerable Upper Intake Level (1.0mg)
17% of ingredients have research evidence

C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 445mg is 445.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Tablet(s) Serving Size

90 Servings

Fat/Fatty Acid Product Type

17% Evidence Coverage

Supplement Facts — Evidence Check

Total Carbohydrates

Folate

445 mcg DFE (111% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 445.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 445mg UL 1.0mg

Beta-Sitosterol

333 mg

Campesterol

167 mg

Stigmasterol

92 mg

Other Plant Sterols

117 mg

Other Ingredients

Plant Sterol Complex Microcrystalline Cellulose Croscarmellose Sodium Cellulose Stearic Acid Silica Calcium L-5-Methyltetrahydrofolate

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (77% of products) Nutrient (60% of products) Approved Health (5% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions: Take one tablet with each meal or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Caution: Keep out of the reach of children.

Practitioner Exclusive

Contains: Soy.

🧪 Formulation Notes

Meta-Sitosterol 2.0 is a naturally derived vegetable preparation featuring enhanced levels of a balanced concentrate of plant sterols - 2 grams per day - which may help to maintain healthy blood levels already within the normal range. Also features the active, preferred form of folate (L-5-methyltetrahydrofolate) to support healthy homocysteine metabolism and cardiovascular health.

The National Institute of Health recommends a healthy diet, along with the consumption of 2 grams of plant sterols daily, to promote cardiovascular health.

This gluten-free and vegetarian.

Certified Gluten Free GFCO.org (Gluten-Free Certification Organization)

Plant sterol complex for support of healthy cholesterol levels

Additional Information

Do not refrigerate (Refrigeration may cause moisture condensation)

Certified Gluten Free GFCO.org (Gluten-Free Certification Organization)

Product Details

UPC / SKU 7 55571 91066 0

DSLD Entry Date 2023-08-23

Product Type Fat/Fatty Acid

Form Tablet or Pill

Brand Metagenics

DSLD ID 295795

Data Updated 2026-04-11

Research Evidence

363 Research Sources

57 Avg Quality Score

187 Meta Analysis

56 Systematic Review

54 Rct

29 Guideline

26 Clinical Trial

6 Cochrane Review

2 Regulatory Source

1 Other

1 Openfda Safety

A Homocysteine-lowering interventions for preventing cardiovascular events

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI

A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI

A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies

Meta Analysis Digestive diseases and sciences 2021

PubMed DOI

A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis

Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021

PubMed DOI

A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Meta Analysis Nutrients 2024

PubMed DOI

A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis

Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025

PubMed DOI

A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies

Meta Analysis Critical reviews in food science and nutrition 2019

PubMed DOI

A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials

Meta Analysis Critical reviews in food science and nutrition 2022

PubMed DOI

A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants

Meta Analysis Critical reviews in food science and nutrition 2023

PubMed DOI

A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care

Meta Analysis The Cochrane database of systematic reviews 2025

PubMed DOI

View all evidence for Folate →