HisSynergy by Metagenics — Ingredients, Evidence & Safety

Product Label

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Label Data

1 Tablet(s) Serving Size

60 Servings

Botanical Product Type

33% Evidence Coverage

Supplement Facts — Evidence Check

Tribulus Fruit Extract

250 mg

Ashwagandha Root Extract

200 mg

📊 Market median: 450.0mg (502 products) 📚 28 studies (Tier A: 0, B: 8)

This product: 200mg

Cowage Seed Extract

50 mg

Other Ingredients

Microcrystalline Cellulose Cellulose Croscarmellose Sodium Stearic Acid Silica Hypromellose Medium Chain Triglyceride Hydroxypropyl Cellulose

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (90% of products) Nutrient (7% of products)

Target Groups

Vegetarian Adult Male (18-50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions: Take as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Caution: If taking levodopa containing medications, consult your healthcare practitioner before use.

To be taken under supervision of a healthcare provider.

Keep out of the reach of children.

Practitioner Exclusive

🧪 Formulation Notes

HisSynergy provides premium Ayurvedic herbal extract support for heathy male sexual function, libido, and vitality - in one formula.

This product is non-GMO, gluten-free, and vegetarian.

Certified gluten free GFCO.org (Gluten Free Certification Organization)

Male libido support

Additional Information

Certified gluten free GFCO.org (Gluten Free Certification Organization)

Product Details

UPC / SKU 7 55571 93841 1

DSLD Entry Date 2023-08-23

Product Type Botanical

Form Tablet or Pill

Brand Metagenics

DSLD ID 295749

Data Updated 2026-04-11

Research Evidence

63 Research Sources

54 Avg Quality Score

26 Systematic Review

21 Rct

11 Meta Analysis

5 Clinical Trial

B Identifying immunostimulatory herbal supplements that may flare autoimmune skin diseases: a systematic scoping review

Systematic Review Lupus science & medicine 2025

PubMed DOI

B Effects of Ashwagandha (Withania somnifera) on VO2max: A Systematic Review and Meta-Analysis

Meta Analysis Nutrients 2020

PubMed DOI

B Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Phytotherapy research : PTR 2022

PubMed DOI

B An update on the efficacy of anti-inflammatory agents for patients with schizophrenia: a meta-analysis

Meta Analysis Psychological medicine 2019

PubMed DOI

B Safety and efficacy of Withania somnifera for anxiety and insomnia: Systematic review and meta-analysis

Meta Analysis Human psychopharmacology 2024

PubMed DOI

B Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis

Meta Analysis PloS one 2021

PubMed DOI

B Plant-derived nootropics and human cognition: A systematic review

Systematic Review Critical reviews in food science and nutrition 2023

PubMed DOI

B Effects of Ashwagandha (Withania Somnifera) on stress and anxiety: A systematic review and meta-analysis

Meta Analysis Explore (New York, N.Y.) 2024

PubMed DOI

B Systematic review and network meta-analysis of the effects of plant active substance on quality of life in breast cancer patients

Systematic Review Frontiers in pharmacology 2025

PubMed DOI

B Clinical evidence for the adaptogenic effects of Withania somnifera and Rhodiola rosea - A systematic review with molecular interpretation of psychometric outcomes

Systematic Review Annals of agricultural and environmental medicine : AAEM 2026

PubMed DOI

View all evidence for Ashwagandha →