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Arginine Plus

product on market Tablet or Pill Metagenics Safety: 90/100
90/100

This product looks safe

  • Folate: 665mg is 665.0× the Tolerable Upper Intake Level (1.0mg)
  • 25% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

L-arginine and glycine are amino acids used to support nitrogen balance and cellular function, though evidence for specific clinical outcomes is often limited. Folate provides essential support for DNA synthesis and methylation. Overall, the evidence coverage for this specific ingredient profile is very low.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 665mg is 665.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Arginine Plus
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Tablet(s)
Serving Size
60
Servings
Fiber and Other Nutrients
Product Type
25%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Total Carbohydrates
1 Gram(s) (1% DV)
665 mcg DFE (166% DV)
Exceeds UL by 665.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
1.5 Gram(s)
Market median: 500.0mg (143 products)
Glycine
10 mg

Other Ingredients

Microcrystalline Cellulose Cellulose Stearic Acid Silica Calcium Silicate Croscarmellose Sodium Hypromellose Medium Chain Triglyceride Hydroxypropyl Cellulose
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take two tablets two times daily or as directed by your healthcare practitioner.

Warnings & Precautions

Caution: If pregnant or nursing, or taking medications, consult your healthcare practitioner before use.

If you have had a myocardial infarction (heart attack) or have a history of renal (kidney) impairment, consult your cardiologist or physician before use.

Keep out of the reach of children.

Practitioner exclusive

Formulation Notes

Arginine Plus delivers high quality L-arginine with calcium L-5-methyltetrahydrofolate to support healthy blood flow, homocysteine levels, and overall cardiovascular health. Providing L-5-methyltetrahydrofolate helps to ensure improved folate nutrition, even in those with genetic variations in folate metabolism.

This product is non GMO, gluten free, and vegetarian.

This product is non GMO, gluten free, and vegetarian.

Support for healthy cardiovascular function

Additional Information

Storage: Keep tightly closed in a cool, dry place. Do not refrigerate.

Certified Gluten Free GFCO.org

Metadata

Product Details

UPC / SKU7 55571 91055 4
DSLD Entry Date2023-08-23
Product TypeFiber and Other Nutrients
FormTablet or Pill
BrandMetagenics
DSLD ID295630
Data Updated2026-04-11
Research

Research Evidence

45
Research Sources
52
Avg Quality
12
Rct
11
Systematic Review
11
Meta Analysis
11
Clinical Trial
A Nitric oxide donors (nitrates), L-arginine, or nitric oxide synthase inhibitors for acute stroke
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Arginine supplementation for prevention of necrotising enterocolitis in preterm infants
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
B Nutritional interventions for treating foot ulcers in people with diabetes
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Nitric oxide donors (nitrates), L-arginine, or nitric oxide synthase inhibitors for acute stroke
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B Arginine supplementation for prevention of necrotising enterocolitis in preterm infants
Systematic Review The Cochrane database of systematic reviews 2007 PubMed
B The Effect of Amino Acids on Wound Healing: A Systematic Review and Meta-Analysis on Arginine and Glutamine
Meta Analysis Nutrients 2021 PubMed DOI
B Nitric oxide donors (nitrates), L-arginine, or nitric oxide synthase inhibitors for acute ischaemic stroke
Systematic Review The Cochrane database of systematic reviews 2000 PubMed
B Dietary Supplements for Erectile Dysfunction: Analysis of Marketed Products, Systematic Review, Meta-Analysis and Rational Use
Meta Analysis Nutrients 2023 PubMed DOI
B Arginine supplementation for prevention of necrotising enterocolitis in preterm infants
Systematic Review The Cochrane database of systematic reviews 2004 PubMed
B An Analysis of Popular Online Erectile Dysfunction Supplements
Systematic Review The journal of sexual medicine 2019 PubMed DOI
View all evidence for L Arginine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.