🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 25% of ingredients have research evidence
B Label Compliance Grade

Product Label

📸

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Label Data

3.3 Gram(s) Serving Size
30 Servings
Other Combinations Product Type
25% Evidence Coverage

Supplement Facts — Evidence Check

Calories
10 {Calories}
Total Carbohydrates
2 Gram(s) (1% DV)
Potassium
95 mg (3% DV)
📊 Market median: 100.0mg (284 products) 📚 10 studies (Tier A: 0, B: 4)
This product: 25mg
Red Wine extract
25 mg
Pine bark extract
25 mg
📊 Market median: 100.0mg (120 products)
Median 100.0mg This product: 25mg
📊 Market median: 500.0mg (283 products) 📚 173 studies (Tier A: 0, B: 62)
This product: 25mg

Other Ingredients

Fructose Glucose Citric Acid Maltodextrin Silica Calcium Sulfate Food Starch Pectin

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (85% of products) Nutrient (9% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions for use: Pour 1 level, white bottle capful of powder into the overcap. Add water to the line on the overcap (2 fl. oz/60mL) and stir. As a dietary supplement, take once daily or as directed by your healthcare provider. Take 2 capfuls per 150 pounds of body weight daily for the first 7-10 days, and take 1 capful thereafter as a maintenance program. Maximum absorption occurs when taken on an empty stomach. This product is isotonic only if the specified amounts of powder and water are used.

As a dietary supplement, take once daily or as directed by your healthcare provider. Take 2 capfuls per 150 pounds of body weight daily for the first 7-10 days, and take 1 capful thereafter as a maintenance program. Maximum absorption occurs when taken on an empty stomach. This product is isotonic only if the specified amounts of powder and water are used.

⚠️ Warnings & Precautions

WARNING: If you are currently using prescription drugs, have an ongoing medical condition, or if you are pregnant or breastfeeding, consult your healthcare provider before using this product.

KEEP OUT OF REACH OF CHILDREN.

Do not use if safety seal is broken or missing.

🧪 Formulation Notes

This vegetarian product contains no added wheat, soy, yeast, gluten, artificial flavor, salt, preservatives or milk.

This vegetarian product contains no added wheat, soy, yeast, gluten, artificial flavor, salt, preservatives or milk.

Additional Information

Powerful antioxidant Promotes cardiovascular and joint health Helps maintain healthy cholesterol and blood glucose levels Demonstrates anti-inflammatory activity Supports normal blood vessel function

The world's most advanced nutraceuticals

PYCNOGENOL(R) NATURES SUPER ANTIOXIDANT

REV 0410

Lot#: Best when used by:

Store in a cool, dry place.

Product Details

DSLD Entry Date 2014-01-24
Product Type Other Combinations
Form Powder
Brand Isotonix
DSLD ID 29518
Data Updated 2026-04-11

Research Evidence

14 Research Sources
50 Avg Quality Score
9 Rct
2 Meta Analysis
2 Clinical Trial
1 Systematic Review
B Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipidemia: A Multicenter, Randomized Controlled Trial
Rct Nutrients 2023
B Efficacy of Bilberry and Grape Seed Extract Supplement Interventions to Improve Glucose and Cholesterol Metabolism and Blood Pressure in Different Populations-A Systematic Review of the Literature
Systematic Review Nutrients 2021
B The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trials
Meta Analysis Journal of the American Dietetic Association 2011
B The impact of grape seed extract treatment on blood pressure changes: A meta-analysis of 16 randomized controlled trials
Meta Analysis Medicine 2016
B Grape Seed Extract Positively Modulates Blood Pressure and Perceived Stress: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Volunteers
Rct Nutrients 2021
C Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial
Rct The British journal of nutrition 2016
C Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome
Rct Metabolism: clinical and experimental 2009
C Grape seed extract supplementation along with a restricted-calorie diet improves cardiovascular risk factors in obese or overweight adult individuals: A randomized, placebo-controlled trial
Rct Phytotherapy research : PTR 2021
C The effect of polyphenol-rich chardonnay seed supplements on peripheral endothelial function.
Rct European journal of nutrition
C The effects of grape seed extract supplementation on cardiovascular risk factors, liver enzymes and hepatic steatosis in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled study.
Rct BMC complementary medicine and therapies
View all evidence for Grape Seed →

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