🟡 60/100

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  • Niacin: 1000mg is 28.6× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
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Safety Alerts

⚠️ Niacin: 1000mg is 28.6× the Tolerable Upper Intake Level (35mg)

The safety score is low because the 1000mg dose of niacin significantly exceeds the recommended daily upper limit of 35mg.

Label Data

1 Tablet(s) Serving Size
90 Servings
Vitamin Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

1000 mg (6250% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 28.6× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 1000mg UL 35mg

Other Ingredients

Microcrystalline Cellulose Stearic Acid Hypromellose Sunflower Lecithin Triethyl Citrate Silicon Dioxide

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested use: Take 1 tablet daily with a meal.

⚠️ Warnings & Precautions

Caution: For adults only.

Consult a physician if pregnant/nursing, taking medication, or have a medical condition (liver problems, stomach ulcers, diabetes, gout, etc.)

Keep out of reach of children.

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, tree nut or sesame ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

🧪 Formulation Notes

Niacinamide (Vitamin B-3) is a form of niacin, a water soluble B-vitamin. It is a derivative of niacin that does not cause the "flush" normally associated with taking high doses of niacin. Niacinamide is readily converted into the bioactive forms of niacin, NAD+, NADH, NADP, NADPH, which are vital cofactors in cellular energy production and are critical for the maintenance of DNA stability.

Natural color variation may occur in this product.

Energy production

Vitamin B-3, No flush

Non-GMO

Vegetarian/Vegan

Vitamins

Made and quality tested in the USA with globally sourced ingredients.

Niacinamide and niacin are two different forms of vitamin B-3. Niacinamide does not cause a niacin flush.

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, tree nut or sesame ingredients.

Additional Information

Store in a cool, dry place after opening.

GMP Quality Assured

Family owned since 1968.

Product Details

UPC / SKU 7 33739 00451 2
DSLD Entry Date 2023-05-24
Product Type Vitamin
Form Tablet or Pill
Brand NOW
DSLD ID 292056
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
View all evidence for Niacin →

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