🟢 90/100

This product looks safe

  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 12% of ingredients have research evidence
B Label Compliance Grade

Product Label

📸

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Safety Alerts

ℹ️ Contains proprietary blend — exact ingredient amounts not disclosed

Label Data

1 Caplet(s) Serving Size
216 Servings
Other Combinations Product Type
12% Evidence Coverage

Supplement Facts — Evidence Check

Total Calories
Total Fat
Sodium
5 mg (1% DV)
Protein
1 Gram(s) (2% DV)
Calcium
38 mg (4% DV)
Iron
2.3 mg (13% DV)
📊 Market median: 80.0mg (20 products) 📚 334 studies (Tier A: 8, B: 183)
This product: 610mg
Ionic Plant Based Minerals
285 mg

Other Ingredients

Calcium Carbonate Sodium Croscarmellose Silica Magnesium Stearate Rice Dextrin Vegetable Coating Protease, Bacterial Probiotic Cultures

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (91% of products) Nutrient (14% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Suggested Use: Adults take 1 caplet 3 times per day with 8 ounces of water or juice. Best taken on an empty stomach. Begin with 1 caplet per day and gradually increase to suggested amount.

⚠️ Warnings & Precautions

Probiotics are cultured in dairy,which is generally consumed during the fermentation process.

Warning: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose, call your doctor or poison control immediately.

Caution: As with any dietary supplement, consult your healthcare practitioner before using this product, especially if you are pregnant, nursing anticipate surgery, take medication on a regular basis or are otherwise under medical supervision.

Caution: As with any dietary supplement, consult your healthcare practitioner before using this product, especially if you are pregnant, nursing anticipate surgery, take medication on a regular basis or are otherwise under medical supervision.

Keep out of reach of children.

Do not use if safety seal is broken or missing.

🧪 Formulation Notes

Vegetarian.

Gluten Free.

Vegetarian.

Gluten Free. Contains no artificial colors or preservatives.

Additional Information

Made in the U.S.A.

CERTIFIED RENEWABLE ENERGY(R) Green-e.org

We Buy 100% Certified Renewable Energy

Recyclable Bottle

PDC216L-120709-050510 200549-216LY-02235268

VALUE PACK- 216 for the price of 180!

Primal Defense is created using the following probiotic species or their enzymes: -Lactobacillus acidophilus -Lactobacillus casei -Bifidobacterium longum -Lactobacillus rhamnosus -Lactobaillus brevis -Bacillus subtilis -Latobacillus salivarius -Bifidobacterium bifidum -Saccharomyces boulardii -Lactobacillus plantarum -Bifidobacterium breve -Lactobacillus paracasei -Bifidobacterium lactis

Store in a cool, dry place.

This product is made with natural ingredients; therefore color may vary from lot to lot.

Product Details

UPC / SKU 6 58010 11294 9
DSLD Entry Date 2013-12-24
Product Type Other Combinations
Form Other (e.g. tea bag)
DSLD ID 28961
Data Updated 2026-04-11

Research Evidence

691 Research Sources
52 Avg Quality Score
255 Clinical Trial
205 Meta Analysis
123 Rct
81 Systematic Review
18 Cochrane Review
2 Guideline
2 Regulatory Source
1 Other
1 Narrative Review
1 Openfda Safety
A Probiotics for preventing acute upper respiratory tract infections
Systematic Review The Cochrane database of systematic reviews 2022
A Probiotics for preventing acute upper respiratory tract infections
Meta Analysis The Cochrane database of systematic reviews 2015
A Probiotics for maintenance of remission in ulcerative colitis
Meta Analysis The Cochrane database of systematic reviews 2020
A Probiotics for induction of remission in ulcerative colitis
Meta Analysis The Cochrane database of systematic reviews 2020
A Probiotics for preventing acute upper respiratory tract infections
Meta Analysis The Cochrane database of systematic reviews 2011
A Probiotics for treating eczema
Meta Analysis The Cochrane database of systematic reviews 2018
A Probiotics for treating acute infectious diarrhoea
Meta Analysis The Cochrane database of systematic reviews 2020
A The Gut Microbiome in Depression and Potential Benefit of Prebiotics, Probiotics and Synbiotics: A Systematic Review of Clinical Trials and Observational Studies
Systematic Review International journal of molecular sciences 2022
A Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children
Meta Analysis The Cochrane database of systematic reviews 2017
A Probiotics to prevent infantile colic
Meta Analysis The Cochrane database of systematic reviews 2019
View all evidence for Probiotics →

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