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B-12/Folate

product on market Lozenge Beyond Health Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Vitamin B-12, B-6, and folate are essential nutrients that support neurological function and homocysteine regulation. There is strong evidence that these ingredients are critical for DNA synthesis and red blood cell formation. This specific profile focuses on these core B-vitamins to maintain metabolic health.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for B-12/Folate
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Lozenge(s)
Serving Size
90
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

5 mg (294% DV)
3.8× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
800 mcg (200% DV)
2.0× RDA — within safe limits 226 studies (A:10, B:105)
2 mg (83300% DV)
833.3× RDA — above typical dose 139 studies (A:1, B:44)

Other Ingredients

Xylitol Microcrystalline Cellulose Croscarmellose Sodium natural Strawberry flavor Stevia leaf extract Stearic Acid Magnesium Stearate Citric Acid
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a dietary supplement, take one (1) to six (6) lozenges daily or as directed by your health professional

Warnings & Precautions

Keep out of reach of children.

Do not use product if the tamper-resistant shrink band around the cap or the inner seal beneath the cap appears to have been tampered with or is missing.

Formulation Notes

Does not contain: Citrus, wheat, rye, oats, corn, barley, gluten, soy, egg, dairy, sugar, yeast, sulfates, chlorides, wax (other than beeswax), preservatives, colorings, or artificial flavorings. No GMO's

Manufactured in the U.S.A.

Additional Information

Must be stored with cap on tightly in a cool, dry place.

World class supplements

Metadata

Product Details

UPC / SKU6 01706 66369 0
DSLD Entry Date2023-03-22
Product TypeVitamin
FormLozenge
DSLD ID283286
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.