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  • Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
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Safety Alerts

⚠️ Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)

The safety score is low because the 500mg dose of niacin significantly exceeds the recommended maximum daily intake of 35mg.

Label Data

1 Tablet(s) Serving Size
100 Servings
Vitamin Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

500 mg (3125% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 14.3× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 500mg UL 35mg

Other Ingredients

Hypromellose Microcrystalline Cellulose Stearic Acid Vegetarian Coating Silica

Label Claims — Verification

All Other
Structure/Function
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested Usage: Take 1 tablet daily with a meal. This high potency tablet should be taken under doctor's supervision.

⚠️ Warnings & Precautions

Niacin supplements may sometimes temporarily cause flushing and/or itching, but this sustained release tablet should minimize those symptoms. To further limit these uncomfortable but not dangerous symptoms, take daily and avoid missing doses. Caution: For adults only. Physician supervision is recommended while taking this product.

Not recommended for pregnant/nursing women. Notify physician if taking medication (especially anticoagulant medications, including NSAIDs) or have a medical condition (especially cardiovascular disease, liver problems, inflammatory bowel disease, diabetes, gout, or migraine headaches).

Transient GI symptoms may occur at inception of treatment, consult physician if symptoms persist.

Keep out of reach of children.

To report a serious adverse event, or for product information, contact 1-800-234-8686

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

🧪 Formulation Notes

Sustained release

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.

Natural color variation may occur in this product.

Additional Information

Douglas Cooper Co. "Trace Minerals Make the Difference" Since 1950

Store in a cool, dry place after opening.

Product Details

DSLD Entry Date 2022-10-24
Product Type Vitamin
Form Tablet or Pill
DSLD ID 275242
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
View all evidence for Niacin →

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