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L-Tryptophan 1,000 mg

product on market Tablet or Pill Source Naturals Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

L-Tryptophan serves as a precursor to serotonin and melatonin, while Vitamin B6 acts as a cofactor in their synthesis. There is moderate evidence supporting their role in mood regulation and sleep quality. However, overall evidence coverage for this specific formulation remains very limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for L-Tryptophan 1,000 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
45
Servings
Other Combinations
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

44 mg (2200% DV)
33.8× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
2 Gram(s)
Market median: 500.0mg (70 products)

Other Ingredients

Microcrystalline Cellulose Stearic Acid modified Cellulose Gum Magnesium Stearate Silica
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: 1 tablet 1 to 2 times daily, between meals and preferably with fruit juice. To support restful sleep, take 2 tablets before bed.

Warnings & Precautions

Caution: If you are pregnant, may become pregnant, breastfeeding, or are taking medications such as SSRIs or MAOIs consult your health care professional before using this product.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

This product may cause drowsiness.

Formulation Notes

L-Tryptophan with Vitamin B-6

Mood, relaxation, sleep

The essential amino acid L-tryptophan is the precursor for the synthesis of melatonin and serotonin, a hormone and a neurotransmitter involved with mood and stress response. It helps support relaxation, restful sleep, and a positive outlook. This tryptophan tablet includes vitamin B-6, which is required to convert tryptophan to serotonin. If needed, L-tryptophan is converted to niacin in the body, an important B vitamin. Source Naturals L-Tryptophan is extremely pure and is regularly tested to ensure the highest standards of quality.

Contains no yeast, dairy, egg, gluten, soy or wheat. Contains no preservatives, or artificial color, flavor or fragrance.

Additional Information

Store in a cool, dry place.

Metadata

Product Details

UPC / SKU0 21078 02610 5
DSLD Entry Date2022-11-22
Product TypeOther Combinations
FormTablet or Pill
DSLD ID274811
Data Updated2026-04-11
Research

Research Evidence

29
Research Sources
48
Avg Quality
19
Rct
5
Meta Analysis
3
Systematic Review
2
Clinical Trial
B Prebiotic and probiotic supplementation and the tryptophan-kynurenine pathway: A systematic review and meta analysis
Meta Analysis Neuroscience and biobehavioral reviews 2021 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression
Meta Analysis Nutrition reviews 2022 PubMed DOI
B No effects of acute tryptophan depletion on anxiety or mood in weight-recovered female patients with anorexia nervosa
Rct European archives of psychiatry and clinical neuroscience 2023 PubMed DOI
C The association between tryptophan levels and postpartum mood disorders: a systematic review and meta-analysis
Meta Analysis BMC psychiatry 2022 PubMed DOI
C A systematic review of the effect of L-tryptophan supplementation on mood and emotional functioning
Systematic Review Journal of dietary supplements 2021 PubMed DOI
C Comparison between Acupuncture and Nutraceutical Treatment with Migratens® in Patients with Fibromyalgia Syndrome: A Prospective Randomized Clinical Trial.
Rct Nutrients PubMed DOI
C Intake of Lactiplantibacillus plantarum HEAL9 Improves Cognition in Moderately Stressed Subjects: A Randomized Controlled Study.
Rct Nutrients PubMed DOI
C Are tryptophan and 5-hydroxytryptophan effective treatments for depression? A meta-analysis
Meta Analysis The Australian and New Zealand journal of psychiatry 2002 PubMed
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.