🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Tablet(s) Serving Size
28 Servings
Other Combinations Product Type
50% Evidence Coverage

Supplement Facts — Evidence Check

Calories
Total Carbohydrates
1 Gram(s) (1% DV)
Vitamin C
90 mg (100% DV)
3 mg (27% DV)
✅ Within RDA (0.3× RDA of 11 mg) 📚 258 studies (Tier A: 6, B: 134)
RDA 11mg This product: 3mg UL 40mg
📊 Market median: 80.0mg (20 products) 📚 334 studies (Tier A: 8, B: 183)
This product: 53mg
📊 Market median: 175.0mg (497 products) 📚 11 studies (Tier A: 0, B: 1)
This product: 100mg

Other Ingredients

Xylitol Mannitol Hydroxypropyl Cellulose Stearic Acid Natural Flavors Magnesium Stearate Stevia leaf extract Vegetable Juice

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (91% of products) Nutrient (14% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Once daily

Directions: Take one (1) tablet daily. Tablet may be chewed or swallowed as desired. Continued use is suggested.

⚠️ Warnings & Precautions

Tamper Evident: Product is sealed within a vial. Do not use if any part of the vial is torn, open or damaged. When first taking Culturelle, you may experience minor bloating, gas or intestinal gurgling which should subside with continued use. Consult your healthcare professional if symptoms persist after two weeks. For questions, concerns or to report an adverse event, please call (800) 722-3476. www.Culturelle.com

Keep out of reach of children.

Inform a healthcare professional before starting any dietary supplement, particularly if there is a known immune-compromised condition.

Not a reduced calorie food.

🧪 Formulation Notes

Culturelle Immune Defense Probiotic leverages a powerful blend containing the #1 clinically studied probiotic, plus Vitamin C, Vitamin C, Zinc, & Elderberry. It helps keep you feeling your best all year long: Zinc Vitamin D Vitamin C Elderberry made with real naturally-sourced elderberry fruit, these chewables taste great. 4-in-1 Immune Support The combination of Lactobacillus rhamnosus GG, Vitamin C, Vitamin D, & Zinc provides 4-in-1 immune support to help keep your immune system strong all year long, both before & after vaccination.

Most clinically researched strain in the world Guaranteed purity & potency

Dairy Gluten Soy Free

Immune defense probiotic with vitamins C & D, Zinc + Elderberry

Helps keep your immune system strong before & after vaccination

Great mixed berry flavor with other natural flavors

Allergy Friendly

While this product contains an ingredient sourced from wheat, it meets the FDA's definition of gluten free (less than 20 ppm gluten).

Additional Information

Storage Instructions: Store Culturelle in a cool, dry place away from direct sunlight.

Our brand values We’re on a mission to inspire better health & wellness for you & your family. We believe in integrity, so we hold ourselves to the highest standards of truth. We believe in the natural power of your body’s microbiome, & in scientific research & products that will unlock its full potential. We believe in uncompromising quality, safety & proven efficacy. We believe in empowering you to embrace every day with confidence.

#1 Clinically studied probiotic Based on the number of Lactobacillus rhamnosus GG clinical studies, as of January 2021.

Guaranteed potency through date on box when stored as directed.

Product Details

UPC / SKU 0 49100 40122 5
DSLD Entry Date 2022-09-22
Product Type Other Combinations
Form Tablet or Pill
Brand Culturelle
DSLD ID 273839
Data Updated 2026-04-11

Research Evidence

691 Research Sources
52 Avg Quality Score
255 Clinical Trial
205 Meta Analysis
123 Rct
81 Systematic Review
18 Cochrane Review
2 Guideline
2 Regulatory Source
1 Other
1 Narrative Review
1 Openfda Safety
A Probiotics for preventing acute upper respiratory tract infections
Systematic Review The Cochrane database of systematic reviews 2022
A Probiotics for preventing acute upper respiratory tract infections
Meta Analysis The Cochrane database of systematic reviews 2015
A Probiotics for maintenance of remission in ulcerative colitis
Meta Analysis The Cochrane database of systematic reviews 2020
A Probiotics for induction of remission in ulcerative colitis
Meta Analysis The Cochrane database of systematic reviews 2020
A Probiotics for preventing acute upper respiratory tract infections
Meta Analysis The Cochrane database of systematic reviews 2011
A Probiotics for treating eczema
Meta Analysis The Cochrane database of systematic reviews 2018
A Probiotics for treating acute infectious diarrhoea
Meta Analysis The Cochrane database of systematic reviews 2020
A The Gut Microbiome in Depression and Potential Benefit of Prebiotics, Probiotics and Synbiotics: A Systematic Review of Clinical Trials and Observational Studies
Systematic Review International journal of molecular sciences 2022
A Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children
Meta Analysis The Cochrane database of systematic reviews 2017
A Probiotics to prevent infantile colic
Meta Analysis The Cochrane database of systematic reviews 2019
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