🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade

Product Label

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Label Data

1 Tablet(s) Serving Size
180 Servings
Non-Nutrient/Non-Botanical Product Type
0% Evidence Coverage

Supplement Facts — Evidence Check

📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews
This product: 650mg
Pepsin
165 mg

Other Ingredients

Stearic Acid Microcrystalline Cellulose Hydroxypropyl Cellulose modified Cellulose Gum Silica

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (82% of products) Nutrient (8% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free Sugar Free

Product Information

📋 Directions for Use

Suggested Use: 1 tablet with a meal, up to four times daily. Do not take on an empty stomach.

⚠️ Warnings & Precautions

Contains milk.

Caution: Do not use if you are pregnant, may become pregnant, or breastfeeding.

If a burning sensation is experienced, discontinue use, or use less frequently.

Warning: If you have stomach or duodenal ulcers, or are taking drugs that may cause ulcers, do not take this product.

Do not use if either tamper-evident seal is broken or missing.

Keep out of reach of children.

🧪 Formulation Notes

Hydrochloric acid source

Digestive support

In the stomach, hydrochloric acid converts prepsinogen to pepsin, an enzyme that breaks down protein. Pepsin breaks down proteins into smaller, more easily absorbed substances. As people age, hydrochloric acid secretion may be reduced, which can result in decreased levels of pepsin. Without proper pepsin levels, the body has a difficult time digesting food. Betaine hydrochloride is used as a supplemental source of hydrochloric acid, which can be utilized by the stomach to produce pepsin. The combination of betaine hydrochloride and pepsin provide an excellent stomach tonic.

Contains no yeast, egg, gluten, corn, soy or wheat. Contains no sugar, starch, preservatives, or artificial color, flavor or fragrance.

Product Details

UPC / SKU 0 21078 01362 4
DSLD Entry Date 2022-09-22
Product Type Non-Nutrient/Non-Botanical
Form Tablet or Pill
DSLD ID 273119
Data Updated 2026-04-11

Research Evidence

23 Research Sources
47 Avg Quality Score
18 Rct
3 Systematic Review
1 Meta Analysis
1 Clinical Trial
B Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine
Rct Nutrients 2016
C Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial
Rct Hepatology (Baltimore, Md.) 2009
C Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency
Systematic Review Journal of inherited metabolic disease 2017
C Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines
Systematic Review Journal of inherited metabolic disease 2015
C Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial
Rct European journal of nutrition 2023
C Association of Betaine-Homocysteine S-Methyl Transferase (rs3797546 and rs3733890) polymorphisms with non-syndromic cleft lip/palate: A meta-analysis
Meta Analysis International orthodontics 2019
C Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver.
Rct The American journal of clinical nutrition
C Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention.
Rct Clinical nutrition ESPEN
C Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.
Rct The American journal of clinical nutrition
C Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine
Rct Cardiovascular drugs and therapy 2009
View all evidence for Betaine →

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