🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade

Product Label

📸

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Label Data

1 Capsule(s) Serving Size
90 Servings
Non-Nutrient/Non-Botanical Product Type
0% Evidence Coverage

Supplement Facts — Evidence Check

100 mg
📊 Market median: 30.0mg (45 products)
Median 30.0mg This product: 100mg
📊 Market median: 50.0mg (57 products) 📚 17 studies — no high-quality reviews
This product: 25mg UL 50mg

Other Ingredients

Gelatin Magnesium Stearate Rice Flour

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (58% of products) Nutrient (4% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Suggested Use: As a dietary supplement, take 1 capsule per day, or as directed by your physician.

⚠️ Warnings & Precautions

Warning: Do not exceed recommended dose.

Pregnant or nursing women, children under 18 and individuals with known medical condition should consult their physician prior to taking.

Pregnant or nursing women, children under 18 and individuals with known medical condition should consult their physician prior to taking. Keep out of reach of children.

Do not use if safety seal is damaged or missing.

🧪 Formulation Notes

Adrenal and metabolic support

Additional Information

Store in a cool, dry place.

GMP Good Manufacturing Practice

Made in USA

To reorder visit: HoltraCeuticals.com

Product Details

UPC / SKU 8 37654 69365 0
DSLD Entry Date 2022-07-21
Product Type Non-Nutrient/Non-Botanical
Form Capsule
DSLD ID 270841
Data Updated 2026-04-11

Research Evidence

9 Research Sources
38 Avg Quality Score
5 Rct
2 Narrative Review
2 Other
B Effect of Pregnenolone vs Placebo on Self-reported Chronic Low Back Pain Among US Military Veterans: A Randomized Clinical Trial
Rct JAMA network open 2020
C Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder
Rct Biomolecules 2022
C Pregnenolone for cognition and mood in dual diagnosis patients
Rct Psychiatry research 2010
C Reduced urine pregnenolone concentration after clinical response in patients with depression: An open-label short-term prospective study
Rct Psychoneuroendocrinology 2023
C Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia
Rct Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009
D Mitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cells
Other The Journal of biological chemistry 2023
D Increased steroid hormone dehydroepiandrosterone and pregnenolone levels in post-mortem brain samples of alcoholics
Other Alcohol (Fayetteville, N.Y.) 2016
D Pregnenolone sulfate in the brain: a controversial neurosteroid
Narrative Review Neurochemistry international 2008
D Individual differences in cognitive aging: implication of pregnenolone sulfate
Narrative Review Progress in neurobiology 2003
View all evidence for Pregnenolone →

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