Twilight Time

product on market Capsule Progressive Professional from Progressive Laboratories 🟢 Safety: 100/100
Brand: Progressive Professional from Progressive Laboratories
🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Capsule(s) Serving Size
30 Servings
Other Combinations Product Type
50% Evidence Coverage

Supplement Facts — Evidence Check

40 mg (2000% DV)
📊 30.8× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 40mg UL 100mg
500 mg
📊 Market median: 500.0mg (70 products)
Median 500.0mg This product: 500mg
Lemon Balm extract
300 mg
200 mg
📊 Market median: 200.0mg (358 products) 📚 9 studies (Tier A: 0, B: 2)
This product: 200mg
Hops extract
120 mg
5 mg
📊 Market median: 3.0mg (984 products) 📚 236 studies (Tier A: 2, B: 109)
This product: 5mg UL 10mg

Other Ingredients

Gelatin Silica

Label Claims — Verification

❓ All Other
❓ Structure/Function
All Other (98% of products) Structure/Function (89% of products) Nutrient (43% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Directions: One or two capsules one hour before bedtime, or more, as directed by a health care professional.

⚠️ Warnings & Precautions

Sold only for dispensing by a licensed health professional.

Tamper evident band around cap and seal on bottle. Do not use if either seal is broken or missing.

Keep out of the reach of children.

Warning: If you are pregnant, breastfeeding, or are taking medications such as SSRI's or MAOI's consult your health care professional before using this product.

May cause drowsiness.

🧪 Formulation Notes

Progressive Laboratories manufactured this product in its 3rd party GMP-inspected facility. (Good Manufacturing Practices)

Mood and sleep support

Additional Information

GMP Good Manufacturing Practice Certified GMP Compliant 21 CFR 111

Product Details

UPC / SKU 3 51821 01017 5
DSLD Entry Date 2022-04-11
Product Type Other Combinations
Form Capsule
Brand Progressive Professional from Progressive Laboratories
DSLD ID 263260
Data Updated 2026-04-11

Research Evidence

153 Research Sources
55 Avg Quality Score
71 Systematic Review
51 Meta Analysis
19 Rct
6 Clinical Trial
2 Other
2 Regulatory Source
1 Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013
PubMed DOI
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009
PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
PubMed DOI
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
PubMed DOI
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
PubMed DOI Cochrane
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021
PubMed DOI
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016
PubMed DOI
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020
PubMed DOI
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006
PubMed Cochrane
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022
PubMed DOI
View all evidence for Vitamin B6 →

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