🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade

Product Label

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Label Data

2 Tablet(s) Serving Size
15 Servings
Non-Nutrient/Non-Botanical Product Type
0% Evidence Coverage

Supplement Facts — Evidence Check

📊 Market median: 500.0mg (193 products) 📚 7 studies — no high-quality reviews
This product: 400mg

Other Ingredients

Cellulose Mannitol Glyceryl Behenate Vegetable Magnesium Stearate Silicon Dioxide Sodium Starch Glycolate Methacrylate Copolymers Magnesium Silicate Triethyl Citrate Riboflavin

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (79% of products) Nutrient (9% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: For adults, we recommend taking two (2) tablets daily, preferably on an empty stomach. In order to obtain maximum benefits, SAM-e should be taken at least 30 minutes prior to a meal.

⚠️ Warnings & Precautions

Tamper evident: Do not use this product if imprinted foil seal under cap is broken or missing.

Caution: You should consult your physician before using SAM-e if you are taking MAO inhibitors. Like all supplements, SAM-e is not intended for use by children and you should consult your physician before using SAM-e if you are pregnant or nursing.

Like all supplements, SAM-e is not intended for use by children and you should consult your physician before using SAM-e if you are pregnant or nursing.

Discontinue use and consult your physician if gastrointestinal discomfort occurs.

Keep out of reach of children.

🧪 Formulation Notes

All living things contain SAM-e (S-adenosylmethionine). The body makes SAM-e from the amino acid methionine. However, you may not be able to obtain sufficient methionine levels simply by ingesting food. In addition, because of age or other factors, levels of SAM-e can fluctuate or decline. Supplementation with SAM-e is the easiest way to increase intake. SAM-e is involved in over 36 biochemical reactions involving enzymatic transmethylation. The methylation process is the mechanism by which the body rids itself of potentially damaging compounds, synthesizes neurotransmitters, makes components of cartilage, regulates enzyme activity within the cell and maintains the flexibility of cell membranes. Science has been looking into this remarkable supplement and time after time clinical studies have drawn the same conclusions. SAM-e promotes healthy joint function and comfort, boosts mood and emotional well-being. SAM-e is a revolutionary supplement. Because of its popularity and use, it has received widespread exposure in the press. Information has appeared in newspapers, magazines, on the internet, or simply through word of mouth. Whether you're a first time SAM-e user or have been a fan for years, you probably have some questions. Please see enclosed insert for more information.

A note about our enteric coating: SAM-e is enterically coated so that you receive optimal absorption. The enteric coating ensures that the breakdown of SAM-e occurs in the small intestine. Clinical trials indicate that absorption is more efficient in the small intestine rather than in the stomach. In addition, the enteric coating is designed to protect SAM-e from moisture. The lack of an enteric coating should not be harmful to the stomach, and there have been no reported cases to this effect. However, the enteric coating serves as a protective barrier so that SAM-e can be absorbed where it can provide you with the greatest benefits.

S-adenosylmethionine

Promotes healthy joint function and comfort Boosts mood and emotional well-being Supports healthy liver function

Gluten free

SAM-e discovered in Italy in 1952 and has been one of Europe's best kept secret for years. Through extensive testing, SAM-e has been shown to be well tolerated by most. But, perhaps the best news is that SAM-e has been found to be a safe, nontoxic supplement for nearly everyone in levels of up to 1,600 mg per day.

Manufactured in an FDA Registered Facility using Good Manufacturing Practices (GMPs).

Suitable for vegetarians/vegans

Contains no wheat, soy, dairy, egg, fish/shellfish, peanuts/tree nuts.

Made in USA

Additional Information

Reorder #2222

Keep tightly closed. Store at room temperature: 59 degrees – 86 degrees F (15 degrees – 30 degrees C).

Product Details

DSLD Entry Date 2021-12-18
Product Type Non-Nutrient/Non-Botanical
Form Tablet or Pill
DSLD ID 262949
Data Updated 2026-04-11

Research Evidence

14 Research Sources
50 Avg Quality Score
8 Rct
4 Meta Analysis
2 Clinical Trial
B The Effect of Fenugreek in Type 2 Diabetes and Prediabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis International journal of molecular sciences 2023
B A randomized controlled clinical trial evaluating the effect of Trigonella foenum-graecum (fenugreek) versus glibenclamide in patients with diabetes
Rct African health sciences 2019
C The effect of fenugreek seed supplementation on serum irisin levels, blood pressure, and liver and kidney function in patients with type 2 diabetes mellitus: A parallel randomized clinical trial
Rct Complementary therapies in medicine 2020
C Effect of saffron and fenugreek on lowering blood glucose: A systematic review with meta-analysis
Meta Analysis Phytotherapy research : PTR 2023
C Effect of fenugreek on hyperglycaemia and hyperlipidemia in diabetes and prediabetes: A meta-analysis
Meta Analysis Journal of ethnopharmacology 2016
C Effect of fenugreek extract supplement on testosterone levels in male: A meta-analysis of clinical trials
Meta Analysis Phytotherapy research : PTR 2020
C Investigating the Effectiveness of Fenugreek on the Quantity of Breast Milk and the Level of Prolactin in Mothers of Preterm Newborns: A Randomized Controlled Clinical Trial
Rct Current drug research reviews 2025
C Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus
Rct Chinese journal of integrative medicine 2008
C Impact of Fenugreek Supplementation on Obesity and Hyperglycemia Among Diabetic Adults in Saudi Arabia
Clinical Trial ClinicalTrials.gov 2025
C Fenugreek bread: a treatment for diabetes mellitus
Rct Journal of medicinal food 2009
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