🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade

Product Label

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Label Data

1 Capsule(s) Serving Size
100 Servings
Non-Nutrient/Non-Botanical Product Type
0% Evidence Coverage

Supplement Facts — Evidence Check

50 mg
📊 Market median: 30.0mg (45 products)
Median 30.0mg This product: 50mg

Other Ingredients

Rice Flour Gelatin Vegetable Stearate

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (58% of products) Nutrient (4% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Dosage and Use Take one capsule daily preferably early in the day on an empty stomach, or as recommended by a healthcare practitioner.

⚠️ Warnings & Precautions

Caution Pregnenolone may affect levels of other hormones, such as progesterone, estrogen, testosterone and/or DHEA. Do not take this product if you have a history of seizures. Do not take this product if you have breast cancer, prostate cancer, or other hormone-sensitive diseases.

Warnings KEEP OUT OF REACH OF CHILDREN.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

DO NOT EXCEED RECOMMENDED DOSE.

Do not purchase if outer seal is broken or damaged.

🧪 Formulation Notes

Contains rice.

This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, or corn. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.

Additional Information

Item Catalog Number: 00302

It is made directly from cholesterol within the mitochondria of the adrenal glands and, to a lesser degree, the nervous system, with the help of the cholesterol side chain cleavage enzyme, p450scc. Pregnenolone is a precursor to various hormones, such as progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. So it can help the body maintain normal hormone levels, which in turn helps numerous body functions.23-32 References

Supports Memory and Hormonal Balance

Product Details

DSLD Entry Date 2013-10-25
Product Type Non-Nutrient/Non-Botanical
Form Capsule
DSLD ID 26180
Data Updated 2026-04-11

Research Evidence

9 Research Sources
38 Avg Quality Score
5 Rct
2 Narrative Review
2 Other
B Effect of Pregnenolone vs Placebo on Self-reported Chronic Low Back Pain Among US Military Veterans: A Randomized Clinical Trial
Rct JAMA network open 2020
C Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder
Rct Biomolecules 2022
C Pregnenolone for cognition and mood in dual diagnosis patients
Rct Psychiatry research 2010
C Reduced urine pregnenolone concentration after clinical response in patients with depression: An open-label short-term prospective study
Rct Psychoneuroendocrinology 2023
C Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia
Rct Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009
D Mitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cells
Other The Journal of biological chemistry 2023
D Increased steroid hormone dehydroepiandrosterone and pregnenolone levels in post-mortem brain samples of alcoholics
Other Alcohol (Fayetteville, N.Y.) 2016
D Pregnenolone sulfate in the brain: a controversial neurosteroid
Narrative Review Neurochemistry international 2008
D Individual differences in cognitive aging: implication of pregnenolone sulfate
Narrative Review Progress in neurobiology 2003
View all evidence for Pregnenolone →

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