Osteo Bi-Flex Double Strength

product on market Softgel Capsule Osteo Bi-Flex 🟢 Safety: 100/100
Brand: Osteo Bi-Flex
🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 11% of ingredients have research evidence
B Label Compliance Grade

Product Label

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Label Data

3 Softgel(s) Serving Size
16 Servings
Other Combinations Product Type
11% Evidence Coverage

Supplement Facts — Evidence Check

Calories
20 {Calories}
Total Fat
2 Gram(s) (2% DV)
Total Carbohydrates
1 Gram(s) (1% DV)
Protein
1 Gram(s) (1% DV)
2 mg (100% DV)
✅ Within RDA (0.9× RDA of 2.3 mg) 📚 8 studies — no high-quality reviews
RDA 2.3mg This product: 2mg UL 11mg
Sodium
45 mg (2% DV)
1500 mg
📊 Market median: 1000.0mg (1115 products) 📚 22 studies (Tier A: 0, B: 9)
This product: 1500mg
Joint Shield(TM) Proprietary Blend
1448 mg
3 mg
📊 Market median: 3.0mg (58 products) 📚 2 studies — no high-quality reviews
This product: 3mg UL 20mg

Other Ingredients

Soybean Oil Glycerin Gelatin Caramel color Soy Lecithin yellow Beeswax

Label Claims — Verification

❓ All Other
❓ Structure/Function
All Other (100% of products) Structure/Function (74% of products) Nutrient (37% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

DIRECTIONS FOR ADULT USE: TAKE THREE (3) SOFTGELS PER DAY PREFERABLY WITH FOOD.

Note: You have the option of taking three softgels together or spread throughout the day.

3 PER DAY

⚠️ Warnings & Precautions

As a reminder, discuss the supplements and medications you take with your health care providers.

CAUTION: If you are pregnant, nursing, taking any medications, planning any medical procedure or have any medical condition, consult your doctor before use.

KEEP OUT OF REACH OF CHILDREN.

TAMPER RESISTANT: DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.

Discontinue use and consult your doctor if any adverse reactions occur.

Contains soy, fish (anchovy, sardine, mackerel) and shellfish (shrimp, crab) ingredients.

Not intended for use by persons under the age of 18.

🧪 Formulation Notes

GLUCOSAMINE CHONDROITIN PLUS JOINT SHIELD(TM)

Contains soy, fish (anchovy, sardine, mackerel) and shellfish (shrimp, crab) ingredients.

Free of Gluten

Additional Information

45232 12K B16052 CAC

20 POINTS 20 POINTS

HELPS REVITALIZE YOUR JOINTS* KEY BUILDING BLOCK OF CARTILAGE*

PROUD SPONSOR of the ARTHRITIS FOUNDATION(TM) Rexall Sundown, Inc., the maker of Osteo Bi-Flex(R), is proud to support the Arthritis Foundation's efforts to help people take control of arthritis. For information about arthritis, contact the Foundation at 1-800-568-4045 or www.arthritis.org

The natural aging process can add excessive stress on your joints. Annoying flare-ups can strike at any time.

STORE AT ROOM TEMPERATURE AND AVOID EXCESSIVE HEAT.

**52 week Nielsen ScanTrack data ending 1/26/13.

Part No. 22-67982 36561

Product Details

UPC / SKU 0 30768 01748 4
DSLD Entry Date 2013-10-25
Product Type Other Combinations
Form Softgel Capsule
Brand Osteo Bi-Flex
DSLD ID 26110
Data Updated 2026-04-11

Research Evidence

11 Research Sources
47 Avg Quality Score
7 Rct
2 Meta Analysis
1 Regulatory Source
C Trace elements and Alzheimer dementia in population-based studies: A bibliometric and meta-analysis
Meta Analysis Environmental pollution (Barking, Essex : 1987) 2023
PubMed DOI
C Proteins involved in iron metabolism in beef cattle are affected by copper deficiency in combination with high dietary manganese, but not by copper deficiency alone
Rct Journal of animal science 2010
PubMed DOI
C Reducing mineral usage in feedlot diets for Nellore cattle: II. Impacts of calcium, phosphorus, copper, manganese, and zinc contents on intake, performance, and liver and bone status
Rct Journal of animal science 2017
PubMed DOI
C Copper, Ceruloplasmin, Zinc, and Manganese Levels in Brain and Biological Fluids from Parkinson's Disease Patients: Systematic Review and Meta-Analysis
Meta Analysis Cells 2026
PubMed DOI
C Risedronate reverses bone loss in postmenopausal women with low bone mass: results from a multinational, double-blind, placebo-controlled trial. BMD-MN Study Group
Rct The Journal of clinical endocrinology and metabolism 2000
PubMed
C Dietary Reference Intakes: Manganese
Regulatory Source IOM/NAM Dietary Reference Intakes 2000
C Vitamins and minerals intake adequacy in hematopoietic stem cell transplant: results of a randomized controlled trial.
Rct Bone marrow transplantation
PubMed DOI
C Collagen Peptides, in Association with Vitamin C, Sodium Hyaluronate, Manganese and Copper, as Part of the Rehabilitation Project in the Treatment of Chronic Low Back Pain.
Rct Endocrine, metabolic & immune disorders drug targets
PubMed DOI
C Glucosamine, chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back: a randomized, double-blind, placebo-controlled pilot study
Rct Military medicine 1999
PubMed
C Effects of a cream containing madecassoside, 5% panthenol, and copper-zinc-manganese on improving postlaser resurfacing wound healing: A split-face, randomized trial.
Rct Dermatologic therapy
PubMed DOI
View all evidence for Manganese →
Manganese research & evidence Best Manganese rankings All Manganese products More from Osteo Bi-Flex View on NIH DSLD →