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Osteo Bi-Flex Double Strength

product on market Softgel Capsule Osteo Bi-Flex Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 11% of ingredients have research evidence
B Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

The listed ingredients primarily consist of basic macronutrients and manganese, a trace mineral involved in bone formation and antioxidant function. Research evidence for these specific components in supporting joint health is limited. The product maintains a high safety profile with no significant concerns noted.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Osteo Bi-Flex Double Strength
Open Full PDF View on NIH DSLD →
Details

Label Data

3 Softgel(s)
Serving Size
16
Servings
Other Combinations
Product Type
11%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
20 {Calories}
Total Fat
2 Gram(s) (2% DV)
Total Carbohydrates
1 Gram(s) (1% DV)
Protein
1 Gram(s) (1% DV)
2 mg (100% DV)
Within RDA (0.9× RDA) 9 studies — no high-quality reviews
Sodium
45 mg (2% DV)
1500 mg
Market median: 1000.0mg (1115 products) 24 studies (A:0, B:9)
Joint Shield(TM) Proprietary Blend
1448 mg
3 mg
Market median: 3.0mg (58 products) 3 studies — no high-quality reviews

Other Ingredients

Soybean Oil Glycerin Gelatin Caramel color Soy Lecithin yellow Beeswax
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

DIRECTIONS FOR ADULT USE: TAKE THREE (3) SOFTGELS PER DAY PREFERABLY WITH FOOD.

Note: You have the option of taking three softgels together or spread throughout the day.

3 PER DAY

Warnings & Precautions

As a reminder, discuss the supplements and medications you take with your health care providers.

CAUTION: If you are pregnant, nursing, taking any medications, planning any medical procedure or have any medical condition, consult your doctor before use.

KEEP OUT OF REACH OF CHILDREN.

TAMPER RESISTANT: DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.

Discontinue use and consult your doctor if any adverse reactions occur.

Contains soy, fish (anchovy, sardine, mackerel) and shellfish (shrimp, crab) ingredients.

Not intended for use by persons under the age of 18.

Formulation Notes

GLUCOSAMINE CHONDROITIN PLUS JOINT SHIELD(TM)

Contains soy, fish (anchovy, sardine, mackerel) and shellfish (shrimp, crab) ingredients.

Free of Gluten

Additional Information

45232 12K B16052 CAC

20 POINTS 20 POINTS

HELPS REVITALIZE YOUR JOINTS* KEY BUILDING BLOCK OF CARTILAGE*

PROUD SPONSOR of the ARTHRITIS FOUNDATION(TM) Rexall Sundown, Inc., the maker of Osteo Bi-Flex(R), is proud to support the Arthritis Foundation's efforts to help people take control of arthritis. For information about arthritis, contact the Foundation at 1-800-568-4045 or www.arthritis.org

The natural aging process can add excessive stress on your joints. Annoying flare-ups can strike at any time.

STORE AT ROOM TEMPERATURE AND AVOID EXCESSIVE HEAT.

**52 week Nielsen ScanTrack data ending 1/26/13.

Part No. 22-67982 36561

Metadata

Product Details

UPC / SKU0 30768 01748 4
DSLD Entry Date2013-10-25
Product TypeOther Combinations
FormSoftgel Capsule
BrandOsteo Bi-Flex
DSLD ID26110
Data Updated2026-04-11
Research

Research Evidence

11
Research Sources
47
Avg Quality
7
Rct
2
Meta Analysis
1
Regulatory Source
C Trace elements and Alzheimer dementia in population-based studies: A bibliometric and meta-analysis
Meta Analysis Environmental pollution (Barking, Essex : 1987) 2023 PubMed DOI
C Proteins involved in iron metabolism in beef cattle are affected by copper deficiency in combination with high dietary manganese, but not by copper deficiency alone
Rct Journal of animal science 2010 PubMed DOI
C Reducing mineral usage in feedlot diets for Nellore cattle: II. Impacts of calcium, phosphorus, copper, manganese, and zinc contents on intake, performance, and liver and bone status
Rct Journal of animal science 2017 PubMed DOI
C Copper, Ceruloplasmin, Zinc, and Manganese Levels in Brain and Biological Fluids from Parkinson's Disease Patients: Systematic Review and Meta-Analysis
Meta Analysis Cells 2026 PubMed DOI
C Risedronate reverses bone loss in postmenopausal women with low bone mass: results from a multinational, double-blind, placebo-controlled trial. BMD-MN Study Group
Rct The Journal of clinical endocrinology and metabolism 2000 PubMed
C Dietary Reference Intakes: Manganese
Regulatory Source IOM/NAM Dietary Reference Intakes 2000
C Vitamins and minerals intake adequacy in hematopoietic stem cell transplant: results of a randomized controlled trial.
Rct Bone marrow transplantation PubMed DOI
C Collagen Peptides, in Association with Vitamin C, Sodium Hyaluronate, Manganese and Copper, as Part of the Rehabilitation Project in the Treatment of Chronic Low Back Pain.
Rct Endocrine, metabolic & immune disorders drug targets PubMed DOI
C Glucosamine, chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back: a randomized, double-blind, placebo-controlled pilot study
Rct Military medicine 1999 PubMed
C Effects of a cream containing madecassoside, 5% panthenol, and copper-zinc-manganese on improving postlaser resurfacing wound healing: A split-face, randomized trial.
Rct Dermatologic therapy PubMed DOI
View all evidence for Manganese →
Manganese research Best Manganese All Manganese products More from Osteo Bi-Flex View on NIH DSLD →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.