Para-Gard by Integrative Therapeutics — Ingredients, Evidence & Safety

🟢 100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
29% of ingredients have research evidence

B Label Compliance Grade

Product Label

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Label Data

1 Capsule(s) Serving Size

20 Servings

Other Combinations Product Type

29% Evidence Coverage

Supplement Facts — Evidence Check

Calories

5 Calorie(s)

Total Carbohydrates

2 Gram(s) (1% DV)

Berberine Sulfate

450 mg

📊 Market median: 500.0mg (234 products) 📚 95 studies (Tier A: 0, B: 35)

This product: 450mg

Gentian (Gentiana lutea) root extract

225 mg

Garlic (Allium sativum) bulb extract

150 mg

📊 Market median: 500.0mg (497 products) 📚 132 studies (Tier A: 0, B: 40)

This product: 150mg

Goldenseal (Hydrastis canadensis) root extract

150 mg

Sweet Wormwood (Artemisia annua) aerial parts extract

150 mg

Other Ingredients

Cellulose plant-derived Capsule Calcium Laurate Silica

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (86% of products) Nutrient (4% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Recommendation: Adults take 1-3 capsules daily or as recommended by a healthcare professional.

⚠️ Warnings & Precautions

Keep out of reach of children.

Do not use if seal under child-resistant cap is broken or missing.

Contains sulfites.

Warning: Do not use if you are pregnant, nursing, have stomach or duodenal ulcers, stomach irritation or inflammation, a bleeding disorder, taking blood thinning medication, or if you are within a week of surgery. If you have diabetes or are taking prescription drugs, consult a healthcare professional before use.

🧪 Formulation Notes

Vegan

Intestinal support botanicals

Contains no wheat, gluten, soy, dairy, or artificial colors, flavors, or preservatives.

Additional Information

Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.

Quality Global Sourcing Bottled & Tested in the USA

Product Details

UPC / SKU 8 71791 00181 7

DSLD Entry Date 2021-06-23

Product Type Other Combinations

Form Capsule

Brand Integrative Therapeutics

DSLD ID 251179

Data Updated 2026-04-11

Research Evidence

98 Research Sources

55 Avg Quality Score

48 Systematic Review

39 Meta Analysis

4 Rct

4 Clinical Trial

1 Other

1 Narrative Review

1 Openfda Safety

B Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials

Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2018

PubMed DOI

B Effects berberine-silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Clinical nutrition ESPEN 2022

PubMed DOI

B Efficacy and safety of berberine for several cardiovascular diseases: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2023

PubMed DOI

B Effect of Berberine on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Complementary therapies in medicine 2019

PubMed DOI

B Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials

Meta Analysis The Journal of nutrition 2023

PubMed DOI

B The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review

Meta Analysis Journal of translational medicine 2024

PubMed DOI

B Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease-Clinical and Pre-Clinical Overview and Systematic Review of the Literature

Systematic Review International journal of molecular sciences 2024

PubMed DOI

B Efficacy and Safety of Berberine Alone or Combined with Statins for the Treatment of Hyperlipidemia: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials

Meta Analysis The American journal of Chinese medicine 2019

PubMed DOI

B Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gut Microbiota Modification: A Meta-Analysis of Animal Studies

Meta Analysis International journal of molecular sciences 2023

PubMed DOI

B Berberine Ursodeoxycholate for the Treatment of Type 2 Diabetes: A Randomized Clinical Trial

Rct JAMA network open 2025

PubMed DOI

View all evidence for Berberine →