EstroWise with Black Cohosh by Earth Wise — Ingredients, Evidence & Safety

Product Label

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Label Data

1 Veggie Capsule(s) Serving Size

45 Servings

Botanical Product Type

50% Evidence Coverage

Supplement Facts — Evidence Check

Black Cohosh

160 mg

📊 Market median: 80.0mg (136 products)

Median 80.0mg This product: 160mg

Soy extract

300 mg

📊 Market median: 60.0mg (94 products) 📚 13 studies (Tier A: 0, B: 7)

This product: 300mg

Red Clover extract

400 mg

Sage leaf extract

500 mg

📊 Market median: 500.0mg (82 products) 📚 19 studies (Tier A: 1, B: 6)

This product: 500mg

Other Ingredients

Vegetable cellulose Rice Flour

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (79% of products) Nutrient (2% of products) No Claim (1% of products)

Target Groups

Adult Female (18 - 50 Years) Menopause Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Directions: Take one capsule, two times daily, preferably on an empty stomach.

⚠️ Warnings & Precautions

Keep out of the reach of children.

Do not use if safety seal under cap is broken or missing.

Contains: Soy.

🧪 Formulation Notes

Black cohosh, soy, red clover and sage all have a traditional history of use by women experiencing change-of-life symptoms. The black cohosh in this formula is phytoequivalent to the black cohosh extract that has been shown in clinical studies to help reduce menopausal symptoms.

Contains No: Gluten, sugar, salt, starch, yeast, corn, wheat, lactose, citrus, milk, egg, fish products, artificial coloring, flavoring, or preservatives.

Made in the USA

Non-GMO

Manufactured in an NSF - GMP Certified Facility

Women's formula

Herbal support to help manage symptoms of menopause

Vitamins & Supplements

Additional Information

Store in a cool dry place. Do not refrigerate.

Please recycle.

In God we trust

Product Details

UPC / SKU 8 12720 01704 2

DSLD Entry Date 2021-05-22

Product Type Botanical

Form Capsule

Brand Earth Wise

DSLD ID 250437

Data Updated 2026-04-11

Research Evidence

31 Research Sources

49 Avg Quality Score

23 Systematic Review

5 Meta Analysis

1 Rct

1 Openfda Safety

B [Efficacy of black cohosh extracts for improving low estrogen status induced by postoperative GnRHa treatment in patients with endometriosis: a systematic review]

Systematic Review Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 2020

PubMed

B Black cohosh (Cimicifuga spp.) for menopausal symptoms

Meta Analysis The Cochrane database of systematic reviews 2012

PubMed DOI

B Vasomotor symptoms resulting from natural menopause: a systematic review and network meta-analysis of treatment effects from the National Institute for Health and Care Excellence guideline on menopause

Systematic Review BJOG : an international journal of obstetrics and gynaecology 2017

PubMed DOI

C Suspected black cohosh hepatotoxicity: no evidence by meta-analysis of randomized controlled clinical trials for isopropanolic black cohosh extract

Meta Analysis Menopause (New York, N.Y.) 2011

PubMed DOI

C Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms - an update on the evidence

Meta Analysis Climacteric : the journal of the International Menopause Society 2021

PubMed DOI

C Menopausal symptoms

Systematic Review BMJ clinical evidence 2007

PubMed

C Menopausal symptoms