🟡 60/100

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  • Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
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Safety Alerts

⚠️ Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)

This product has a low safety score because its 500mg dose of niacin is more than 14 times higher than the recommended maximum daily limit.

Label Data

1 Tablet(s) Serving Size
Vitamin Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

500 mg (3125% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 14.3× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 500mg UL 35mg

Other Ingredients

Microcrystalline Cellulose Lactose Stearic Acid Talc Croscarmellose Sodium Silica

Label Claims — Verification

All Other
Structure/Function
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions: Adults only: One tablet daily, as a dietary supplement, or as directed by a physician.

⚠️ Warnings & Precautions

Tamper resistant - Do not use if imprinted safety seal under cap is broken or missing

Contains milk. Warnings: Do not use this product if you have a known sensitivity or allergy to niacinamide.

Use only under the advice and supervision of a physician if you have any of the following conditions: gallbladder disease or a history of jaundice or liver disease, diabetes, gout or peptic ulcer. Abnormal liver function test have been reported in persons taking daily doses of 500 mg or more of niacinamide.

Keep out of reach of children.

🧪 Formulation Notes

Free of sodium, soy, gluten, preservatives, yeast, corn, artificial colors and flavors.

Additional Information

To preserve quality and freshness, keep bottle tightly closed. Store between 15 degrees - 30 degrees Celsius (59 degrees - 86 degrees Fahrenheit).

Questions or comments? 1-800-645-2158 www.rugbylaboratories.com

Product Details

UPC / SKU 8 80681 01900 9
DSLD Entry Date 2021-05-22
Product Type Vitamin
Form Tablet or Pill
Brand Rugby
DSLD ID 247575
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
View all evidence for Niacin →

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