🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

Product Label

📸

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Label Data

1 Tablet(s) Serving Size
Other Combinations Product Type
50% Evidence Coverage

Supplement Facts — Evidence Check

Calories
5 Calorie(s)
Total Carbohydrates
1 Gram(s) (1% DV)
Sodium
10 mg (1% DV)
10 mcg (50% DV)
✅ Within RDA (0.7× RDA of 0.015 mg) 📚 604 studies (Tier A: 16, B: 251)
RDA 0.015mg This product: 0.01mg UL 0.1mg
1500 mg
📊 Market median: 1000.0mg (1115 products) 📚 22 studies (Tier A: 0, B: 9)
This product: 1500mg
📊 Market median: 375.0mg (171 products) 📚 30 studies (Tier A: 1, B: 14)
This product: 100mg

Other Ingredients

Cellulose Hydroxpropyl Methylcellulose Croscarmellose Contains Less Than 2% of

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (100% of products) Structure/Function (89% of products) Nutrient (16% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions for Adult Use: Take one (1) tablet per day preferably with food.

⚠️ Warnings & Precautions

As a reminder, discuss the supplements and medications you take with your health care providers.

Contains shellfish (crab, crayfish, lobster, shrimp) ingredients.

Keep out of reach of children.

Tamper resistant: Do not use if seal under cap is broken or missing.

Caution: If you are pregnant, nursing, taking any medications, including blood thinners, or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18.

🧪 Formulation Notes

Free of Gluten Non-GMO

Made in the USA with select ingredients from around the world.

Based on two human studies with 5-Loxin Advanced where subjects rated their joint health over time, subjects’ joint health improved within 7 days, and continued to improve throughout the duration of the studies. Based on the results of the Pharmacy Times Survey of Pharmacists’ OTC Recommendations who recommend a “joint health” dietary supplement, 2020-2021.

Joint health Start feeling the difference in your joint comfort in just 7 days with the power of Joint Shield!

Helps to: Strengthen Joints Support Flexibility Support Mobility

Joint Shield is our clinically studied beneficial herbal ingredient that has been shown to significantly improve joint comfort in just 7 days. It is a highly concentrated form of Boswellia Serrata that helps soothe your joints while improving joint function for comfortable movement.

Supports a healthy immune system Shows improved joint comfort within 7 days

Glucosamine with Joint Shield

Range of Motion Made to Move During the day, you move your joints in so many different ways, getting up, sitting down, bending and flexing. Osteo Bi-Flex is America’s #1 Joint Health brand and supports joint comfort, so you can enjoy a range of motion for your day’s activities.

Osteo Bi-Flex One Per Day provides you with joint supporting ingredients with the convenience of only one pill per day. This formula includes glucosamine that helps strengthen your joints and supports healthy cartilage. Vitamin D is also included to help maintain healthy bones in adults.

Osteo Bi-Flex is manufactured under the highest standards for product quality, purity and potency.

Additional Information

Store at room temperature and avoid excessive heat.

Source: IRI Total US – Multi Outlet: Latest 52 weeks ending April, 26 2020 See bottom of box for more information about our Ambassador’s Club 20 points Join the Ambassador’s Club for Rewards Visit www.osteobiflex.com for more information.

#1 Pharmacist Recommended Brand 2020-2021 Joint health U.S. News & World Report Pharmacy Times

To learn more about Osteo Bi-Flex visit www.osteobiflex.com or call us toll free 1-888-vitahelp (848-2435).

Individual results may vary.

Product Details

UPC / SKU 0 30768 33049 1
DSLD Entry Date 2021-03-25
Product Type Other Combinations
Form Tablet or Pill
DSLD ID 242709
Data Updated 2026-04-11

Research Evidence

39 Research Sources
50 Avg Quality Score
20 Rct
9 Meta Analysis
4 Clinical Trial
3 Systematic Review
1 Regulatory Source
1 Openfda Safety
B Interventions for the management of temporomandibular joint osteoarthritis
Systematic Review The Cochrane database of systematic reviews 2012
B Glucosamine therapy for treating osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2005
B Chondroitin for osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2015
B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis
Meta Analysis Archives of orthopaedic and trauma surgery 2023
B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis
Rct The New England journal of medicine 2006
B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review
Systematic Review International journal of molecular sciences 2023
B Scientific Opinion on glucosamine and joint health
Regulatory Source EFSA Journal 2009
B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis
Meta Analysis Computational and mathematical methods in medicine 2022
B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
Rct Annals of the rheumatic diseases 2016
B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials
Meta Analysis Journal of orthopaedic surgery and research 2018
View all evidence for Glucosamine →

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