🟢 90/100

This product looks safe

  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 12% of ingredients have research evidence
B Label Compliance Grade

Product Label

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Safety Alerts

ℹ️ Contains proprietary blend — exact ingredient amounts not disclosed

Label Data

1 Caplet(s) Serving Size
180 Servings
Other Combinations Product Type
12% Evidence Coverage

Supplement Facts — Evidence Check

Total Calories
Total Fat
Sodium
5 mg (1% DV)
Protein
1 Gram(s) (2% DV)
Calcium
38 mg (4% DV)
Iron
2.3 mg (13% DV)
📊 Market median: 80.0mg (20 products) 📚 334 studies (Tier A: 8, B: 183)
This product: 610mg
Ionic Plant Based Minerals
285 mg

Other Ingredients

Calcium Carbonate Sodium Croscarmellose Silica Magnesium Stearate Rice Dextrin Vegetable Coating Protease, Bacterial Probiotic Cultures

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (91% of products) Nutrient (14% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Suggested Use: Adults take 1 caplet 3 times per day with 8 ounces of water or juice. Best taken on an empty stomach. Begin with 1 caplet per day and gradually increase to suggested amount.

⚠️ Warnings & Precautions

Caution: As with any dietary supplement, consult your healthcare practitioner before using this product, especially if you are pregnant, nursing, anticipate surgery, take medication on a regular basis or are otherwise under medical supervision.

Keep out of reach of children.

Do not use if safety seal is broken or missing.

Warning: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose, call your doctor or poison control center immediately.

Not intended for children.

Probiotics are cultured in dairy, which is generally consumed during the fermentation process.

🧪 Formulation Notes

Primal Defense is a natural blend of 12 species of probiotics and Homeostatic Soil Organisms (HSOs), utilizing the Poten-Zyme process and delivered within a whole food matrix. The HSO probiotic blend in Primal Defense helps support normal gastrointestinal balance of good and potentially harmful bacteria to help maintain a balanced, healthy internal environment, and maximizes the benefits of a healthy diet by supporting normal absorption and assimilation of nutrients in the gut. Primal Defense is created using the following probiotic species or their enzymes: Lactobacillus acidophilus Lactobacillus rhamnosus Latobacillus salivarius Lactobacillus plantarum Lactobacillus paracasei Lactobacillus casei Lactobaillus brevis Bifidobacterium bifidum Bifidobacterium breve Bifidobacterium lactis Bifidobacterium longum Bacillus subtilis Saccharomyces boulardii

Contains no artificial colors or preservatives.

This product is made with natural ingredients; therefore color may vary from lot to lot.

Made in the U.S.A.

Vegetarian

Gluten free

Additional Information

Store in a cool, dry place.

Certified renewable energy Green-e.org We Buy 100% Certified Renewable Energy Recyclable bottle

Product Details

UPC / SKU 6 58010 11156 0
DSLD Entry Date 2021-01-22
Product Type Other Combinations
Form Other (e.g. tea bag)
DSLD ID 242656
Data Updated 2026-04-11

Research Evidence

691 Research Sources
52 Avg Quality Score
255 Clinical Trial
205 Meta Analysis
123 Rct
81 Systematic Review
18 Cochrane Review
2 Guideline
2 Regulatory Source
1 Other
1 Narrative Review
1 Openfda Safety
A Probiotics for preventing acute upper respiratory tract infections
Systematic Review The Cochrane database of systematic reviews 2022
A Probiotics for preventing acute upper respiratory tract infections
Meta Analysis The Cochrane database of systematic reviews 2015
A Probiotics for maintenance of remission in ulcerative colitis
Meta Analysis The Cochrane database of systematic reviews 2020
A Probiotics for induction of remission in ulcerative colitis
Meta Analysis The Cochrane database of systematic reviews 2020
A Probiotics for preventing acute upper respiratory tract infections
Meta Analysis The Cochrane database of systematic reviews 2011
A Probiotics for treating eczema
Meta Analysis The Cochrane database of systematic reviews 2018
A Probiotics for treating acute infectious diarrhoea
Meta Analysis The Cochrane database of systematic reviews 2020
A The Gut Microbiome in Depression and Potential Benefit of Prebiotics, Probiotics and Synbiotics: A Systematic Review of Clinical Trials and Observational Studies
Systematic Review International journal of molecular sciences 2022
A Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children
Meta Analysis The Cochrane database of systematic reviews 2017
A Probiotics to prevent infantile colic
Meta Analysis The Cochrane database of systematic reviews 2019
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