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Comprehensive Circulation Support

product on market Capsule Clinical Synergy Professional Formulas Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 33% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

L-carnitine and nattokinase have moderate research evidence for supporting cardiovascular health and fibrinolytic activity. The botanical and mushroom blend has more limited clinical data regarding circulation. Overall, these ingredients are generally well-tolerated with a high safety profile.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Comprehensive Circulation Support
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
33%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Comprehensive Circulation Support Botanical and Organically Grown Medicinal Mushroom Proprietary Blend
1 Gram(s)
100 mg
Market median: 500.0mg (861 products) 61 studies (A:4, B:13)
50 mg
Market median: 100.0mg (70 products)

Other Ingredients

Vegetable Capsule Microcrystalline Cellulose L-Leucine Stearic Acid Silicon Dioxide
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: As a dietary supplement, take 1-2 capsules, 1-2 times per day on an empty stomach, or as directed by your healthcare practitioner.

Warnings & Precautions

CA Residents Prop 65 Warning: This product contains a chemical known to the State of California to cause cancer, birth defects, or other reproductive harm.

Caution: Comprehensive Circulation Support is not recommended during pregnancy or nursing. Please consult your healthcare practitioner if you are taking medicine for a blood disorder.

Nattokinase is not recommended for those allergic to soy.

Formulation Notes

Comprehensive Circulation Support is designed to promote flow of blood, oxygen and nutrients to the organs and tissues.

Nattokinase NSK-SD (vitamin K2 free) is combined with L-Carnitine, botanicals and organically grown medicinal mushrooms for targeted cardiovascular support, focusing on circulation, and healthy blood pressure. NSK-SD supplies fibrinolytic activity to support blood flow. Reishi may maintain nitric oxide production, which helps support smooth blood vessels. Chinese salvia is used throughout Asia for what's known in traditional Asian herbalism as blood stagnation.

Supports blood vessel health Promotes healthy blood circulation Supports cardiovascular health

Comprehensive Circulation Support is vegetarian/vegan safe, gluten-free and non-GMO

Comprehensive Circulation Support is vegetarian/vegan safe, gluten-free and non-GMO

Helps maintain vascular function for healthy blood circulation

Manufactured in the U.S.A.

Metadata

Product Details

UPC / SKU8 92985 00041 6
DSLD Entry Date2020-12-26
Product TypeOther Combinations
FormCapsule
DSLD ID240524
Data Updated2026-04-11
Research

Research Evidence

80
Research Sources
49
Avg Quality
43
Rct
14
Clinical Trial
11
Systematic Review
9
Meta Analysis
2
Regulatory Source
A Propionyl-L-carnitine for intermittent claudication
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
A Carnitine supplements for people with chronic kidney disease requiring dialysis
Systematic Review The Cochrane database of systematic reviews 2022 PubMed DOI
A Acetyl-L-carnitine for patients with hepatic encephalopathy
Meta Analysis The Cochrane database of systematic reviews 2019 PubMed DOI
A Acetyl-L-carnitine for the treatment of diabetic peripheral neuropathy
Meta Analysis The Cochrane database of systematic reviews 2019 PubMed DOI
B Carnitine for fatigue in multiple sclerosis
Systematic Review The Cochrane database of systematic reviews 2012 PubMed DOI
B L-carnitine for cognitive enhancement in people without cognitive impairment
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
B Carnitine for fatigue in multiple sclerosis
Systematic Review The Cochrane database of systematic reviews 2010 PubMed DOI
B Systematic Review and Meta-analysis on Effect of Carnitine, Coenzyme Q10 and Selenium on Pregnancy and Semen Parameters in Couples With Idiopathic Male Infertility
Meta Analysis Urology 2022 PubMed DOI
B Effects of Carnitine and Coenzyme Q10 on Sperm Quality and Pregnancy Rates in Men with Unexplained Infertility: A Systematic Review and Network Meta-Analysis
Systematic Review Reproductive sciences (Thousand Oaks, Calif.) 2025 PubMed DOI
B Efficacy and Effectiveness of Carnitine Supplementation for Cancer-Related Fatigue: A Systematic Literature Review and Meta-Analysis
Meta Analysis Nutrients 2017 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.