🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 33% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Capsule(s) Serving Size
30 Servings
Other Combinations Product Type
33% Evidence Coverage

Supplement Facts — Evidence Check

Comprehensive Circulation Support Botanical and Organically Grown Medicinal Mushroom Proprietary Blend
1 Gram(s)
100 mg
📊 Market median: 500.0mg (861 products) 📚 60 studies (Tier A: 4, B: 13)
This product: 100mg
50 mg
📊 Market median: 100.0mg (70 products)
Median 100.0mg This product: 50mg

Other Ingredients

Vegetable Capsule Microcrystalline Cellulose L-Leucine Stearic Acid Silicon Dioxide

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (88% of products) Nutrient (18% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free

Product Information

📋 Directions for Use

Suggested Use: As a dietary supplement, take 1-2 capsules, 1-2 times per day on an empty stomach, or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

CA Residents Prop 65 Warning: This product contains a chemical known to the State of California to cause cancer, birth defects, or other reproductive harm.

Caution: Comprehensive Circulation Support is not recommended during pregnancy or nursing. Please consult your healthcare practitioner if you are taking medicine for a blood disorder.

Nattokinase is not recommended for those allergic to soy.

🧪 Formulation Notes

Comprehensive Circulation Support is designed to promote flow of blood, oxygen and nutrients to the organs and tissues.

Nattokinase NSK-SD (vitamin K2 free) is combined with L-Carnitine, botanicals and organically grown medicinal mushrooms for targeted cardiovascular support, focusing on circulation, and healthy blood pressure. NSK-SD supplies fibrinolytic activity to support blood flow. Reishi may maintain nitric oxide production, which helps support smooth blood vessels. Chinese salvia is used throughout Asia for what's known in traditional Asian herbalism as blood stagnation.

Supports blood vessel health Promotes healthy blood circulation Supports cardiovascular health

Comprehensive Circulation Support is vegetarian/vegan safe, gluten-free and non-GMO

Comprehensive Circulation Support is vegetarian/vegan safe, gluten-free and non-GMO

Helps maintain vascular function for healthy blood circulation

Manufactured in the U.S.A.

Product Details

UPC / SKU 8 92985 00041 6
DSLD Entry Date 2020-12-26
Product Type Other Combinations
Form Capsule
DSLD ID 240524
Data Updated 2026-04-11

Research Evidence

80 Research Sources
49 Avg Quality Score
43 Rct
14 Clinical Trial
11 Systematic Review
9 Meta Analysis
2 Regulatory Source
A Propionyl-L-carnitine for intermittent claudication
Meta Analysis The Cochrane database of systematic reviews 2021
A Carnitine supplements for people with chronic kidney disease requiring dialysis
Systematic Review The Cochrane database of systematic reviews 2022
A Acetyl-L-carnitine for patients with hepatic encephalopathy
Meta Analysis The Cochrane database of systematic reviews 2019
A Acetyl-L-carnitine for the treatment of diabetic peripheral neuropathy
Meta Analysis The Cochrane database of systematic reviews 2019
B Carnitine for fatigue in multiple sclerosis
Systematic Review The Cochrane database of systematic reviews 2012
B L-carnitine for cognitive enhancement in people without cognitive impairment
Meta Analysis The Cochrane database of systematic reviews 2017
B Carnitine for fatigue in multiple sclerosis
Systematic Review The Cochrane database of systematic reviews 2010
B Systematic Review and Meta-analysis on Effect of Carnitine, Coenzyme Q10 and Selenium on Pregnancy and Semen Parameters in Couples With Idiopathic Male Infertility
Meta Analysis Urology 2022
B Effects of Carnitine and Coenzyme Q10 on Sperm Quality and Pregnancy Rates in Men with Unexplained Infertility: A Systematic Review and Network Meta-Analysis
Systematic Review Reproductive sciences (Thousand Oaks, Calif.) 2025
B Efficacy and Effectiveness of Carnitine Supplementation for Cancer-Related Fatigue: A Systematic Literature Review and Meta-Analysis
Meta Analysis Nutrients 2017
View all evidence for Carnitine →

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