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Migraine Prevention Formula

product on market Tablet or Pill Dr. Knowles Safety: 92/100
92/100

This product looks safe

  • Magnesium: 360mg is 1.0× the Tolerable Upper Intake Level (350mg)
  • 40% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Riboflavin and magnesium have moderate evidence for reducing migraine frequency and severity. Feverfew and butterbur are traditionally used for prevention, though clinical evidence for their efficacy is more limited. The formula maintains a high safety profile based on the provided score.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Magnesium: 360mg is 1.0× the Tolerable Upper Intake Level (350mg)

Label

Product Label

Label for Migraine Prevention Formula
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Extended Release Tablet(s)
Serving Size
90
Servings
Other Combinations
Product Type
40%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

400 mg (23500% DV)
307.7× RDA — above typical dose 13 studies (A:0, B:1)
360 mg (90% DV)
Exceeds UL by 1.0× (UL: 350 mg) 316 studies (A:8, B:159)
Butterbur
150 mg
100 mg
Market median: 380.0mg (120 products) 8 studies — no high-quality reviews
Organic Whole Food Blend
75 mg

Other Ingredients

Cellulose Hydroxypropyl Methycellulose Stearic Acid Magnesium Stearate Silica Pharmaceutical Glaze
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Formulation Notes

Soothing brain support

With standardized butterbur and feverfew, riboflavin and magnesium in an organic, whole food blend

PA free

Vegetarian

Gluten free

Manufactured in an independently certified GMP facility

Additional Information

Formulated by doctors, recommended by medical professionals

Metadata

Product Details

DSLD Entry Date2020-11-21
Product TypeOther Combinations
FormTablet or Pill
BrandDr. Knowles
DSLD ID240210
Data Updated2026-04-11
Research

Research Evidence

22
Research Sources
49
Avg Quality
8
Rct
4
Meta Analysis
4
Clinical Trial
3
Systematic Review
1
Cochrane Review
1
Regulatory Source
B Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis
Systematic Review BMJ open 2024 PubMed DOI
B Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis
Meta Analysis Nutritional neuroscience 2022 PubMed DOI
B Supplementary vitamin E, selenium, cysteine and riboflavin for preventing kwashiorkor in preschool children in developing countries
Systematic Review The Cochrane database of systematic reviews 2010 PubMed DOI
B Riboflavin supplements for blood pressure lowering in adults.
Cochrane Review The Cochrane database of systematic reviews PubMed DOI
B Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2022 PubMed DOI
C Prophylaxis of migraine headaches with riboflavin: A systematic review
Systematic Review Journal of clinical pharmacy and therapeutics 2017 PubMed DOI
C Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trial
Rct Cephalalgia : an international journal of headache 2010 PubMed DOI
C The efficacy of 2 different phakic intraocular lens implant in keratoconus as an isolated procedure or combined with collagen crosslinking and intra-stromal corneal ring segments: a systematic review and meta-analysis
Meta Analysis International ophthalmology 2023 PubMed DOI
C Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis
Meta Analysis The ocular surface 2014 PubMed DOI
C Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial
Rct The journal of headache and pain 2015 PubMed DOI
View all evidence for Riboflavin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.