Glucosamine HCl with MSM by CVS Health — Ingredients, Evidence & Safety

Product Label

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Label Data

2 Caplet(s) Serving Size

75 Servings

Non-Nutrient/Non-Botanical Product Type

25% Evidence Coverage

Supplement Facts — Evidence Check

Calories

8 Calorie(s)

Total Carbohydrates

2 Gram(s) (1% DV)

Glucosamine HCl

1500 mg

📊 Market median: 1000.0mg (1115 products) 📚 22 studies (Tier A: 0, B: 9)

This product: 1500mg

Methylsulfonylmethane

1500 mg

📊 Market median: 1000.0mg (2 products)

This product: 1500mg

Other Ingredients

Microcrystalline Cellulose Polyvinylpyrrolidone Croscarmellose Sodium Hydroxypropylcellulose Stearic Acid Crospovidone Hypromellose Magnesium Stearate Talc Silica Polyethylene Glycol Mineral Oil

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (89% of products) Nutrient (16% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Only 2 caplets per day

Directions: For adults, take two (2) caplets daily, preferably with a meal.

⚠️ Warnings & Precautions

Do not use if printed label under cap is broken or missing

As a reminder, discuss the supplements and medications you take with your health care providers.

Contains: Shellfish (crab and shrimp shell).

Warning: If you are pregnant, nursing, taking any medications, including blood thinners, or have any medication condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Individual results may vary.

Keep out of reach of children.

Tamper resistant: Do not use if seal under cap is broken or missing.

🧪 Formulation Notes

Joint health Supports cartilage health & joint comfort

Glucosamine + MSM is an effective supplement combination that helps support maximum flexibility, range of motion and joint health. Together this duo promotes healthy cartilage and collage development to support fluid joint movement.

Glucosamine is a key component of cartilage, synovial fluid and other connective tissues, which are needed for healthy structure and function of joints

MSM (Methylsulfonylmethane) is a natural source of sulfur and works in conjunction with Glucosamine to support collagen, an important component of healthy joints and connective tissue. This product should be taken on a consistent basis to support joint health.

No yeast, wheat, gluten, milk or milk derivatives, lactose, sugar, preservatives, soy, artificial color, artificial flavor.

Additional Information

CVS Quality Money back guarantee

Store at room temperature and avoid excess heat.

Product Details

UPC / SKU 0 50428 32398 4

DSLD Entry Date 2020-12-26

Product Type Non-Nutrient/Non-Botanical

Form Other (e.g. tea bag)

Brand CVS Health

DSLD ID 239581

Data Updated 2026-04-11

Research Evidence

39 Research Sources

50 Avg Quality Score

20 Rct

9 Meta Analysis

4 Clinical Trial

3 Systematic Review

1 Regulatory Source

1 Openfda Safety

B Interventions for the management of temporomandibular joint osteoarthritis

Systematic Review The Cochrane database of systematic reviews 2012

PubMed DOI Cochrane

B Glucosamine therapy for treating osteoarthritis

Meta Analysis The Cochrane database of systematic reviews 2005

PubMed Cochrane

B Chondroitin for osteoarthritis

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI Cochrane

B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis

Meta Analysis Archives of orthopaedic and trauma surgery 2023

PubMed DOI

B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis

Rct The New England journal of medicine 2006

PubMed

B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review

Systematic Review International journal of molecular sciences 2023

PubMed DOI

B Scientific Opinion on glucosamine and joint health

Regulatory Source EFSA Journal 2009

DOI

B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis

Meta Analysis Computational and mathematical methods in medicine 2022

PubMed DOI

B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib

Rct Annals of the rheumatic diseases 2016

PubMed DOI

B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials

Meta Analysis Journal of orthopaedic surgery and research 2018

PubMed DOI

View all evidence for Glucosamine →