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Glucosamine HCl with MSM

product on market Other (e.g. tea bag) CVS Health Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 25% of ingredients have research evidence
B Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Glucosamine HCl and methylsulfonylmethane (MSM) are commonly used to support joint health and reduce discomfort. Research provides moderate evidence that these ingredients may help manage osteoarthritis symptoms. However, overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Glucosamine HCl with MSM
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Caplet(s)
Serving Size
75
Servings
Non-Nutrient/Non-Botanical
Product Type
25%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
8 Calorie(s)
Total Carbohydrates
2 Gram(s) (1% DV)
1500 mg
Market median: 1000.0mg (1115 products) 24 studies (A:0, B:9)
Market median: 1000.0mg (2 products)

Other Ingredients

Microcrystalline Cellulose Polyvinylpyrrolidone Croscarmellose Sodium Hydroxypropylcellulose Stearic Acid Crospovidone Hypromellose Magnesium Stearate Talc Silica Polyethylene Glycol Mineral Oil
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Only 2 caplets per day

Directions: For adults, take two (2) caplets daily, preferably with a meal.

Warnings & Precautions

Do not use if printed label under cap is broken or missing

As a reminder, discuss the supplements and medications you take with your health care providers.

Contains: Shellfish (crab and shrimp shell).

Warning: If you are pregnant, nursing, taking any medications, including blood thinners, or have any medication condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Individual results may vary.

Keep out of reach of children.

Tamper resistant: Do not use if seal under cap is broken or missing.

Formulation Notes

Joint health Supports cartilage health & joint comfort

Glucosamine + MSM is an effective supplement combination that helps support maximum flexibility, range of motion and joint health. Together this duo promotes healthy cartilage and collage development to support fluid joint movement.

Glucosamine is a key component of cartilage, synovial fluid and other connective tissues, which are needed for healthy structure and function of joints

MSM (Methylsulfonylmethane) is a natural source of sulfur and works in conjunction with Glucosamine to support collagen, an important component of healthy joints and connective tissue. This product should be taken on a consistent basis to support joint health.

No yeast, wheat, gluten, milk or milk derivatives, lactose, sugar, preservatives, soy, artificial color, artificial flavor.

Additional Information

CVS Quality Money back guarantee

Store at room temperature and avoid excess heat.

Metadata

Product Details

UPC / SKU0 50428 32398 4
DSLD Entry Date2020-12-26
Product TypeNon-Nutrient/Non-Botanical
FormOther (e.g. tea bag)
BrandCVS Health
DSLD ID239581
Data Updated2026-04-11
Research

Research Evidence

39
Research Sources
50
Avg Quality
20
Rct
9
Meta Analysis
4
Clinical Trial
3
Systematic Review
1
Regulatory Source
1
Openfda Safety
B Interventions for the management of temporomandibular joint osteoarthritis
Systematic Review The Cochrane database of systematic reviews 2012 PubMed DOI
B Glucosamine therapy for treating osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2005 PubMed
B Chondroitin for osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis
Meta Analysis Archives of orthopaedic and trauma surgery 2023 PubMed DOI
B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis
Rct The New England journal of medicine 2006 PubMed
B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review
Systematic Review International journal of molecular sciences 2023 PubMed DOI
B Scientific Opinion on glucosamine and joint health
Regulatory Source EFSA Journal 2009 DOI
B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis
Meta Analysis Computational and mathematical methods in medicine 2022 PubMed DOI
B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
Rct Annals of the rheumatic diseases 2016 PubMed DOI
B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials
Meta Analysis Journal of orthopaedic surgery and research 2018 PubMed DOI
View all evidence for Glucosamine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.