🟡 60/100

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  • Folate: 8500mg is 8500.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 8500mg is 8500.0× the Tolerable Upper Intake Level (1.0mg)

This product received a low safety score because the amount of folate it contains significantly exceeds the recommended maximum daily limit.

Label Data

1 Vegetarian Tablet(s) Serving Size
Vitamin Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

8500 mcg DFE (2125% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 8500.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 8500mg UL 1.0mg

Other Ingredients

Microcrystalline Cellulose Dicalcium Phosphate Stearic Acid Croscarmellose Sodium Silica Vegetable Stearate

Label Claims — Verification

Nutrient
All Other
All Other (99% of products) Structure/Function (77% of products) Nutrient (60% of products) Approved Health (5% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Read the entire label and follow the directions carefully prior to use. Directions: Take one (1) tablet daily with food, or as recommended by a healthcare practitioner.

⚠️ Warnings & Precautions

Caution: Do not use this product if treated with methotrexate, fluorouracil, phenytoin, phenobarbital, primidone, or levodopa prior to consultation with your personal physician.

Warnings: Keep out of reach of children.

Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

🧪 Formulation Notes

L-Methylfolate 8500 mcg DFE

Gluten free Non GMO LE Certified

Metabolically active form of folic acid

Additional Information

Non GMO LE Certified

Store tightly closed in a cool, dry place.

Product Details

UPC / SKU 7 37870 19133 9
DSLD Entry Date 2020-08-23
Product Type Vitamin
Form Tablet or Pill
DSLD ID 232089
Data Updated 2026-04-11

Research Evidence

363 Research Sources
57 Avg Quality Score
187 Meta Analysis
56 Systematic Review
54 Rct
29 Guideline
26 Clinical Trial
6 Cochrane Review
2 Regulatory Source
1 Other
1 Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025
View all evidence for Folate →

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