Home/ Supplements/ Folate/ Methyl B12 + Folate

Methyl B12 + Folate

product on market Lozenge PureFormulas Safety: 80/100
80/100

This product is generally safe

  • Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Folate and Vitamin B12 are essential nutrients that support cognitive function and red blood cell formation. There is strong clinical evidence regarding their role in maintaining neurological health and reducing homocysteine levels. The current evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Methyl B12 + Folate
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Lozenge(s)
Serving Size
90
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

667 mcg DFE (167% DV)
Exceeds UL by 667.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
1000 mcg (41667% DV)
416.7× RDA — above typical dose 139 studies (A:1, B:44)

Other Ingredients

Xylitol Mannitol natural Cherry flavor natural Berry flavor natural Vanilla flavor Croscarmellose Sodium Hydroxypropyl Cellulose Ascorbyl Palmitate Malic Acid
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

Suggested usage: As a dietary supplement, adults take 1 lozenge daily or as directed by your healthcare professional. Allow lozenge to dissolve in mouth and then swallow.

Warnings & Precautions

Warning: If you are pregnant, nursing, have any health condition or taking any medication, consult your healthcare professional before using this product.

Keep out of reach of children.

Use only if safety seal is intact.

Formulation Notes

Gluten-free, Non-GMO

Additional Information

Store in a cool, dry place.

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.

Live life pure.

% Daily Value (DV)

Metadata

Product Details

UPC / SKUPUF1025
DSLD Entry Date2020-06-24
Product TypeVitamin
FormLozenge
BrandPureFormulas
DSLD ID228490
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
View all evidence for Folate →
Compare

Similar Products

Vitamin B-12 Lozenges 1000 mcg
Vitabase · Lozenge
100
B12 Vitamin 1000 mcg
Meijer Naturals · Lozenge
100
B12 Lozenge 1000 mg Natural Cherry Flavor
Thompson · Lozenge
100
Active B12 Dibencozide With Folic Acid 3000 mcg
Country Life · Lozenge
100
Advanced B-12 Complex 5 mg
Source Naturals · Lozenge
100
View all Folate products →
Folate research Best Folate All Folate products More from PureFormulas View on NIH DSLD →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.