Home/ Supplements/ Folate/ Folic Acid 400 mcg

Folic Acid 400 mcg

product on market Tablet or Pill GNC Safety: 60/100
60/100

Review before taking

  • Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Folate is supported by strong evidence for preventing neural tube defects during pregnancy. However, the safety score of 60 indicates potential concerns that may require professional guidance. This supplement provides a standard dose of folic acid to support cellular growth.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This product received a low safety score because the amount of folate exceeds the recommended maximum daily limit. This means the dosage is significantly higher than the level considered safe for the general population.

Label

Product Label

Label for Folic Acid 400 mcg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

667 mcg DFE (167% DV)
Exceeds UL by 667.0× (UL: 1.0 mg) 226 studies (A:10, B:105)

Other Ingredients

Dextrose Stearic Acid Magnesium Stearate Rice Bran Powder
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Approved Health
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a dietary supplement, take one or two tablets daily.

Warnings & Precautions

Keep out of reach of children.

Folate intake should not exceed 278% of the DV, 1667 mcg DFE (1000 mcg).

Adequate folate in a healthy diet may reduce a woman's risk of having a child with a brain or spinal cord defect.

Formulation Notes

No artificial colors, no artificial flavors, no preservatives, sodium free, no wheat, gluten free, no soy, no dairy.

Supports healthy fetal development Required for proper red blood cell formation

Potency verified by GNC procedure #5050. Conforms to USP <2091> for weight.

Ko Kosher Service

GF Gluten free

Additional Information

Store in a cool, dry place.

100 servings

Ko Kosher Service

Metadata

Product Details

UPC / SKU0 48107 17724 9
DSLD Entry Date2020-06-24
Product TypeVitamin
FormTablet or Pill
BrandGNC
DSLD ID224657
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
View all evidence for Folate →
Compare

Similar Products

Maximum Strength Folic Acid 800 mcg
Nature's Bounty · Tablet or Pill
100
Folic Acid 800 mcg
VitaCeutical Labs · Tablet or Pill
100
Folic Acid 800 mcg With 25 mcg Vitamin B-12
Vitabase · Tablet or Pill
100
Natural Folic Acid 400 mcg
Equaline · Tablet or Pill
100
Folic Acid 400 mcg Supplement
Nature Made · Tablet or Pill
100
View all Folate products →
Folate research Best Folate All Folate products More from GNC View on NIH DSLD →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.