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Folic Acid 400 mcg 680 mcg DFE

product on market Tablet or Pill The Vitamin Shoppe Safety: 60/100
60/100

Review before taking

  • Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Folate is supported by strong evidence for reducing neural tube defects during pregnancy. However, the safety score of 60 indicates potential concerns that may require professional guidance. This supplement provides a standard dose of folic acid to support cellular growth.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This product received a low safety score because the amount of folate exceeds the recommended tolerable upper intake level. This means the dosage is higher than the maximum amount considered safe for daily consumption.

Label

Product Label

Label for Folic Acid 400 mcg 680 mcg DFE
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

680 mcg DFE (170% DV)
Exceeds UL by 680.0× (UL: 1.0 mg) 226 studies (A:10, B:105)

Other Ingredients

Dicalcium Phosphate Microcrystalline Cellulose Brown Rice powder Stearic Acid Magnesium Stearate Croscarmellose Sodium Aqueous film coating
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Qualified Health
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take one (1) tablet daily, preferably with a meal.

Warnings & Precautions

Warning: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication, or have any medical condition.

Keep out of reach of children.

Tamper evident Do not use if outer seal is broken or missing.

Formulation Notes

Cardiovascular health

Prenatal support

Gluten-free Dairy-free Soy-free Nut-free

The FDA acknowledges women who consume healthful diets with adequate folate (folic acid) throughout their childbearing years may reduce their risk of having a child with a birth defect of the brain or spinal cord (neural tube defects). Sources of folate include fruits, vegetables, whole grain products, fortified cereals and dietary supplements.

Additional Information

Vitamin

Quality Promise Tested & Trusted

Store in a cool, dry place.

Metadata

Product Details

UPC / SKU7 66536 02169 7
DSLD Entry Date2020-05-22
Product TypeVitamin
FormTablet or Pill
BrandThe Vitamin Shoppe
DSLD ID221412
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
View all evidence for Folate →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.