What the Evidence Says

The listed top ingredients consist of basic macronutrients and minerals rather than active joint-support compounds. There is limited evidence linking these specific components to joint health improvements. Consequently, the overall evidence coverage for this specific ingredient profile is very low.

AI-generated summary based on research evidence. Not medical advice.

Product Label

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Label Data

2 Tablet(s) Serving Size

60 Servings

Non-Nutrient/Non-Botanical Product Type

25% Evidence Coverage

Supplement Facts — Evidence Check

Calories

5 Calorie(s)

Total Carbohydrates

1 Gram(s) (1% DV)

Protein

0.5 Gram(s) (1% DV)

Sodium

93 mg (4% DV)

Potassium

220 mg (6% DV)

Glucosamine Sulfate

1500 mg

📊 Market median: 1000.0mg (1115 products) 📚 24 studies (Tier A: 0, B: 9)

This product: 1500mg

Chondroitin Sulfate

1200 mg

📊 Market median: 600.0mg (79 products) 📚 25 studies (Tier A: 0, B: 6)

This product: 1200mg

OptiMSM MSM

500 mg

📊 Market median: 1000.0mg (2 products)

This product: 500mg

Other Ingredients

Hydroxypropyl Methylcellulose Microcrystalline Cellulose Calcium Palmitate Aqueous Film Coating Croscarmellose Sodium

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (89% of products) Nutrient (16% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Directions: Take two (2) tablets daily, preferably with a meal.

⚠️ Warnings & Precautions

Contains: Crustacean (Crab, Lobster, Shrimp).

Warning: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medications or have any medical conditions.

Keep out of reach of children.

Tamper evident Do not use if outer seal is broken or missing.

🧪 Formulation Notes

Joint support Mobility Flexibility

Gluten-free Dairy-free Soy-free Nut-free

Does not contain: Gluten, Sugar, Preservatives.

Additional Information

Specialty

Quality promise Tested & trusted

Store in a cool, dry place.

Product Details

UPC / SKU 7 66536 01803 1

DSLD Entry Date 2020-04-23

Product Type Non-Nutrient/Non-Botanical

Form Tablet or Pill

Brand The Vitamin Shoppe

DSLD ID 217682

Data Updated 2026-04-11

Research Evidence

39 Research Sources

50 Avg Quality Score

20 Rct

9 Meta Analysis

4 Clinical Trial

3 Systematic Review

1 Regulatory Source

1 Openfda Safety

B Interventions for the management of temporomandibular joint osteoarthritis

Systematic Review The Cochrane database of systematic reviews 2012

PubMed DOI Cochrane

B Glucosamine therapy for treating osteoarthritis

Meta Analysis The Cochrane database of systematic reviews 2005

PubMed Cochrane

B Chondroitin for osteoarthritis

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI Cochrane

B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis

Meta Analysis Archives of orthopaedic and trauma surgery 2023

PubMed DOI

B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis

Rct The New England journal of medicine 2006

PubMed

B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review

Systematic Review International journal of molecular sciences 2023

PubMed DOI

B Scientific Opinion on glucosamine and joint health

Regulatory Source EFSA Journal 2009

DOI

B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis

Meta Analysis Computational and mathematical methods in medicine 2022

PubMed DOI

B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib

Rct Annals of the rheumatic diseases 2016

PubMed DOI

B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials

Meta Analysis Journal of orthopaedic surgery and research 2018

PubMed DOI

View all evidence for Glucosamine →