🟢 80/100

This product is generally safe

  • Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)
  • 50% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)

Label Data

1 Tablet(s) Serving Size
180 Servings
Botanical with Nutrients Product Type
50% Evidence Coverage

Supplement Facts — Evidence Check

500 mg (3125% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 14.3× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 500mg UL 35mg
Guggul (Commiphora mukul) resin extract
375 mg

Other Ingredients

Microcrystalline Cellulose Stearic Acid Cellulose Magnesium Stearate Silica Croscarmellose Sodium Coating

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free

Product Information

📋 Directions for Use

Directions: Take one tablet three times daily or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Caution: Niacin may be associated with itching and/or other allergic reactions.

Warning: Do not use if pregnant or breastfeeding or if you have a history of gout, kidney, or liver dysfunction. Larger than recommended doses of niacin have been associated with liver dysfunction. If taking cholesterol lowering medications, blood thinners, or using non-steroidal anti-inflammatory medications (NSAIDs) please discuss with your clinician prior to use.

🧪 Formulation Notes

Lipotain is a formula designed to help maintain healthy blood lipids by supplying 500 mg of niacin as inositol hexanicotinate per serving. This unique, sustained-release form of niacin is formulated to be effective without the uncomfortable adverse effects associated with conventional niacin, such as flushing. Lipotain also features a standardized extract of guggul resin, to support healthy blood lipid levels already in the normal range and complement the activities of inositol hexanicotinate.

This product is non-GMO, gluten-free, and vegetarian.

This product is non-GMO, gluten-free, and vegetarian.

Non-flush niacin & guggul for healthy blood lipids

Additional Information

Storage: Keep tightly closed in a cool, dry place.

Non GMO Project Verified nongmoproject.org GF Certified Gluten-free

Practitioner exclusive

Product Details

UPC / SKU 7 55571 91033 2
DSLD Entry Date 2020-03-24
Product Type Botanical with Nutrients
Form Tablet or Pill
Brand Metagenics
DSLD ID 216451
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
View all evidence for Niacin →

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