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Lipotain

product on market Tablet or Pill Metagenics Safety: 80/100
80/100

This product is generally safe

  • Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)
  • 50% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Niacin is supported by strong evidence for managing lipid profiles, while Guggul resin extract has shown limited to moderate effects on cholesterol levels. Overall evidence coverage for this specific combination is very low. The ingredients generally maintain a high safety profile for most users.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)

Label

Product Label

Label for Lipotain
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
180
Servings
Botanical with Nutrients
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

500 mg (3125% DV)
Exceeds UL by 14.3× (UL: 35 mg) 196 studies (A:5, B:63)
Guggul (Commiphora mukul) resin extract
375 mg

Other Ingredients

Microcrystalline Cellulose Stearic Acid Cellulose Magnesium Stearate Silica Croscarmellose Sodium Coating
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take one tablet three times daily or as directed by your healthcare practitioner.

Warnings & Precautions

Caution: Niacin may be associated with itching and/or other allergic reactions.

Warning: Do not use if pregnant or breastfeeding or if you have a history of gout, kidney, or liver dysfunction. Larger than recommended doses of niacin have been associated with liver dysfunction. If taking cholesterol lowering medications, blood thinners, or using non-steroidal anti-inflammatory medications (NSAIDs) please discuss with your clinician prior to use.

Formulation Notes

Lipotain is a formula designed to help maintain healthy blood lipids by supplying 500 mg of niacin as inositol hexanicotinate per serving. This unique, sustained-release form of niacin is formulated to be effective without the uncomfortable adverse effects associated with conventional niacin, such as flushing. Lipotain also features a standardized extract of guggul resin, to support healthy blood lipid levels already in the normal range and complement the activities of inositol hexanicotinate.

This product is non-GMO, gluten-free, and vegetarian.

This product is non-GMO, gluten-free, and vegetarian.

Non-flush niacin & guggul for healthy blood lipids

Additional Information

Storage: Keep tightly closed in a cool, dry place.

Non GMO Project Verified nongmoproject.org GF Certified Gluten-free

Practitioner exclusive

Metadata

Product Details

UPC / SKU7 55571 91033 2
DSLD Entry Date2020-03-24
Product TypeBotanical with Nutrients
FormTablet or Pill
BrandMetagenics
DSLD ID216451
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
View all evidence for Niacin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.