Selestro by Metagenics — Ingredients, Evidence & Safety

Product Label

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Label Data

1 Tablet(s) Serving Size

60 Servings

Botanical Product Type

0% Evidence Coverage

Supplement Facts — Evidence Check

Soybean concentrate

100 mg

Black Cohosh (Actaea racemosa) root & rhizome extract

80 mg

📊 Market median: 80.0mg (136 products)

Median 80.0mg This product: 80mg

Other Ingredients

Microcrystalline Cellulose Soy Isoflavones Black Cohosh extract Stearic Acid Cellulose Silica Sodium Starch Glycolate Coating

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (79% of products) Nutrient (2% of products) No Claim (1% of products)

Target Groups

Vegetarian Women (not pregnant or lactating) Menopause Seniors/Mature (>50 Years) - Women ONLY Gluten Free

Product Information

📋 Directions for Use

Directions: Take one tablet one to two times daily or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Warning: Do not use if pregnant or nursing. Caution: Consult your healthcare practitioner before use if you are taking medication or have a liver disorder or develop symptoms of liver trouble.

Keep out of the reach of children.

Contains: Soy.

🧪 Formulation Notes

Selestro combines soy isoflavones with standardized black cohosh extract to help relieve symptoms such as hot flashes, occasional sleep disturbances, and mild mood swings associated with menopause.

This product is non-GMO, gluten-free, and vegetarian.

Menopausal symptom relief

Additional Information

Storage: Keep tightly closed in a cool, dry place.

Certified Gluten-free

Practitioner exclusive

Product Details

DSLD Entry Date 2019-12-22

Product Type Botanical

Form Tablet or Pill

Brand Metagenics

DSLD ID 209706

Data Updated 2026-04-11

Research Evidence

31 Research Sources

49 Avg Quality Score

23 Systematic Review

5 Meta Analysis

1 Rct

1 Openfda Safety

B [Efficacy of black cohosh extracts for improving low estrogen status induced by postoperative GnRHa treatment in patients with endometriosis: a systematic review]

Systematic Review Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 2020

PubMed

B Black cohosh (Cimicifuga spp.) for menopausal symptoms

Meta Analysis The Cochrane database of systematic reviews 2012

PubMed DOI

B Vasomotor symptoms resulting from natural menopause: a systematic review and network meta-analysis of treatment effects from the National Institute for Health and Care Excellence guideline on menopause

Systematic Review BJOG : an international journal of obstetrics and gynaecology 2017

PubMed DOI

C Suspected black cohosh hepatotoxicity: no evidence by meta-analysis of randomized controlled clinical trials for isopropanolic black cohosh extract

Meta Analysis Menopause (New York, N.Y.) 2011

PubMed DOI

C Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms - an update on the evidence

Meta Analysis Climacteric : the journal of the International Menopause Society 2021

PubMed DOI

C Menopausal symptoms

Systematic Review BMJ clinical evidence 2007

PubMed

C Menopausal symptoms