🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 22% of ingredients have research evidence
B Label Compliance Grade

Product Label

📸

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Label Data

2 Tablet(s) Serving Size
30 Servings
Botanical with Nutrients Product Type
22% Evidence Coverage

Supplement Facts — Evidence Check

Total Carbohydrates
1 Gram(s) (1% DV)
25 mg (1471% DV)
📊 19.2× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 25mg
200 mg (50% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 200mg
📊 Market median: 380.0mg (120 products) 📚 8 studies — no high-quality reviews
This product: 350mg
200 mg
📊 Market median: 495.0mg (70 products)
Median 495.0mg This product: 200mg
Butterbur root extract
100 mg
White Willow
100 mg
Griffonia
50 mg
ActiSorb
10 mg

Other Ingredients

Cellulose Stearic Acid Silica

Label Claims — Verification

All Other
All Other (99% of products) Structure/Function (85% of products) Nutrient (48% of products) No Claim (1% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating)

Product Information

📋 Directions for Use

2 Daily

Directions: Use only as directed. Take 2 tablets as needed.

⚠️ Warnings & Precautions

Warning: Do not use if safety seal is broken or missing.

Keep out of reach of children.

Keep your licensed health care practitioner informed when using this product.

Do not use if you are pregnant.

Not recommended for long-term use.

Directions: Use only as directed.

🧪 Formulation Notes

Complex Capillary Formula includes Butterbur, Magnesium, Feverfew, Guarana and White Willow

Additional Information

Innovative quality Since 1932

Clinical Lifestyles

Store in a cool, dry place.

Discussion: MigraDefense is intended to provide nutritive support for normal, healthy capillary function and smooth muscle stasis.

Product Details

DSLD Entry Date 2019-11-21
Product Type Botanical with Nutrients
Form Tablet or Pill
Brand KAL
DSLD ID 207731
Data Updated 2026-04-11

Research Evidence

22 Research Sources
49 Avg Quality Score
8 Rct
4 Meta Analysis
4 Clinical Trial
3 Systematic Review
1 Cochrane Review
1 Regulatory Source
B Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis
Systematic Review BMJ open 2024
B Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis
Meta Analysis Nutritional neuroscience 2022
B Supplementary vitamin E, selenium, cysteine and riboflavin for preventing kwashiorkor in preschool children in developing countries
Systematic Review The Cochrane database of systematic reviews 2010
B Riboflavin supplements for blood pressure lowering in adults.
Cochrane Review The Cochrane database of systematic reviews
B Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2022
C Prophylaxis of migraine headaches with riboflavin: A systematic review
Systematic Review Journal of clinical pharmacy and therapeutics 2017
C Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trial
Rct Cephalalgia : an international journal of headache 2010
C The efficacy of 2 different phakic intraocular lens implant in keratoconus as an isolated procedure or combined with collagen crosslinking and intra-stromal corneal ring segments: a systematic review and meta-analysis
Meta Analysis International ophthalmology 2023
C Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis
Meta Analysis The ocular surface 2014
C Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial
Rct The journal of headache and pain 2015
View all evidence for Riboflavin →

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