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MigraDefense

product on market Tablet or Pill KAL Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 22% of ingredients have research evidence
B Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Riboflavin and magnesium are supported by moderate evidence for reducing migraine frequency and severity. Feverfew and guarana are included for their traditional use in managing head pain, though clinical evidence for these specific extracts is more limited. The formulation focuses on nutrient-based support for neurological function.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for MigraDefense
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Tablet(s)
Serving Size
30
Servings
Botanical with Nutrients
Product Type
22%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Total Carbohydrates
1 Gram(s) (1% DV)
25 mg (1471% DV)
19.2× RDA — above typical dose 13 studies (A:0, B:1)
200 mg (50% DV)
Within RDA (0.5× RDA) 316 studies (A:8, B:159)
Market median: 380.0mg (120 products) 8 studies — no high-quality reviews
200 mg
Market median: 495.0mg (70 products)
Butterbur root extract
100 mg
White Willow
100 mg
Griffonia
50 mg
ActiSorb
10 mg

Other Ingredients

Cellulose Stearic Acid Silica
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

2 Daily

Directions: Use only as directed. Take 2 tablets as needed.

Warnings & Precautions

Warning: Do not use if safety seal is broken or missing.

Keep out of reach of children.

Keep your licensed health care practitioner informed when using this product.

Do not use if you are pregnant.

Not recommended for long-term use.

Directions: Use only as directed.

Formulation Notes

Complex Capillary Formula includes Butterbur, Magnesium, Feverfew, Guarana and White Willow

Additional Information

Innovative quality Since 1932

Clinical Lifestyles

Store in a cool, dry place.

Discussion: MigraDefense is intended to provide nutritive support for normal, healthy capillary function and smooth muscle stasis.

Metadata

Product Details

DSLD Entry Date2019-11-21
Product TypeBotanical with Nutrients
FormTablet or Pill
BrandKAL
DSLD ID207731
Data Updated2026-04-11
Research

Research Evidence

22
Research Sources
49
Avg Quality
8
Rct
4
Meta Analysis
4
Clinical Trial
3
Systematic Review
1
Cochrane Review
1
Regulatory Source
B Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis
Systematic Review BMJ open 2024 PubMed DOI
B Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis
Meta Analysis Nutritional neuroscience 2022 PubMed DOI
B Supplementary vitamin E, selenium, cysteine and riboflavin for preventing kwashiorkor in preschool children in developing countries
Systematic Review The Cochrane database of systematic reviews 2010 PubMed DOI
B Riboflavin supplements for blood pressure lowering in adults.
Cochrane Review The Cochrane database of systematic reviews PubMed DOI
B Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2022 PubMed DOI
C Prophylaxis of migraine headaches with riboflavin: A systematic review
Systematic Review Journal of clinical pharmacy and therapeutics 2017 PubMed DOI
C Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trial
Rct Cephalalgia : an international journal of headache 2010 PubMed DOI
C The efficacy of 2 different phakic intraocular lens implant in keratoconus as an isolated procedure or combined with collagen crosslinking and intra-stromal corneal ring segments: a systematic review and meta-analysis
Meta Analysis International ophthalmology 2023 PubMed DOI
C Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis
Meta Analysis The ocular surface 2014 PubMed DOI
C Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial
Rct The journal of headache and pain 2015 PubMed DOI
View all evidence for Riboflavin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.