🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 60% of ingredients have research evidence
A Label Compliance Grade

Product Label

📸

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Label Data

1 Tablet(s) Serving Size
Other Combinations Product Type
60% Evidence Coverage

Supplement Facts — Evidence Check

Calories
5 Calorie(s)
Total Carbohydrates
1 Gram(s) (1% DV)
10 mcg (50% DV)
✅ Within RDA (0.7× RDA of 0.015 mg) 📚 604 studies (Tier A: 16, B: 251)
RDA 0.015mg This product: 0.01mg UL 0.1mg
1500 mg
📊 Market median: 1000.0mg (1115 products) 📚 22 studies (Tier A: 0, B: 9)
This product: 1500mg
📊 Market median: 375.0mg (171 products) 📚 30 studies (Tier A: 1, B: 14)
This product: 100mg

Other Ingredients

Cellulose Stearic Acid Contains Less Than 2% of

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (100% of products) Structure/Function (89% of products) Nutrient (16% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions: As a dietary supplement, adults take one (1) tablet daily with any meal or as directed by a healthcare provider. Do not exceed recommended dosage.

One per day

⚠️ Warnings & Precautions

Do not exceed recommended dosage.

Warning: If you are diabetic, consult your physician before using this product.

If you have a Shellfish allergy please consult your physician before using this product.

Warning: Consult a healthcare provider prior to use if pregnant, nursing, on medications, have a medical condition or are planning a medical procedure.

Stop use and contact a physician if adverse reactions occur.

Keep out of reach of children.

Do not use if product appears to be tampered with or seal is broken.

Contains shellfish (shrimp, crab, lobster, crayfish).

🧪 Formulation Notes

Glucosamine Hydrochloride supports joints and cartilage health. Plus the added Vitamin D3 supports bone strength and your immune system.

No Artificial Flavors. Gluten Free.

+ Vitamin D3

Contains shellfish (shrimp, crab, lobster, crayfish).

Additional Information

Individual results may vary.

Store at room temperature.

Advanced Joint Support Compare vs. Osteo Bi-Flex One Per Day

Guaranteed quality Laboratory tested

Product Details

UPC / SKU 7 40985 27708 9
DSLD Entry Date 2019-09-24
Product Type Other Combinations
Form Tablet or Pill
Brand 21st Century
DSLD ID 207133
Data Updated 2026-04-11

Research Evidence

39 Research Sources
50 Avg Quality Score
20 Rct
9 Meta Analysis
4 Clinical Trial
3 Systematic Review
1 Regulatory Source
1 Openfda Safety
B Interventions for the management of temporomandibular joint osteoarthritis
Systematic Review The Cochrane database of systematic reviews 2012
B Glucosamine therapy for treating osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2005
B Chondroitin for osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2015
B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis
Meta Analysis Archives of orthopaedic and trauma surgery 2023
B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis
Rct The New England journal of medicine 2006
B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review
Systematic Review International journal of molecular sciences 2023
B Scientific Opinion on glucosamine and joint health
Regulatory Source EFSA Journal 2009
B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis
Meta Analysis Computational and mathematical methods in medicine 2022
B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
Rct Annals of the rheumatic diseases 2016
B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials
Meta Analysis Journal of orthopaedic surgery and research 2018
View all evidence for Glucosamine →

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