Glucosamine 500 mg Chondroitin 400 mg by 21st Century — Ingredients, Evidence & Safety

Product Label

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Label Data

1 Capsule(s) Serving Size

70 Servings

Other Combinations Product Type

33% Evidence Coverage

Supplement Facts — Evidence Check

Calories

10 Calorie(s)

Total Carbohydrates

2 Gram(s) (1% DV)

Sodium

120 mg (6% DV)

Potassium

195 mg (4% DV)

Glucosamine Sulfate

1500 mg

📊 Market median: 1000.0mg (1115 products) 📚 22 studies (Tier A: 0, B: 9)

This product: 1500mg

Chondroitin Sulfate

1200 mg

📊 Market median: 600.0mg (79 products) 📚 24 studies (Tier A: 0, B: 6)

This product: 1200mg

Other Ingredients

Gelatin Contains Less Than 2% of

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (89% of products) Nutrient (16% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions: As a dietary supplement, adults take one (1) capsule with any meal, three (3) times daily or as directed by a healthcare provider. Do not exceed recommended dosage.

3 capsules daily

⚠️ Warnings & Precautions

Do not exceed recommended dosage.

Warning: If you are diabetic consult your physician before using this product.

If you have a Shellfish allergy, please consult your healthcare provider before using this product.

Warning: Consult a healthcare provider prior to use if pregnant, nursing, on medications, have a medical condition or are planning a medical procedure.

Stop use and contact a physician if adverse reactions occur.

Keep out of reach of children.

Do not use if product appears to be tampered with or seal is broken.

Contains shellfish (shrimp, crab, lobster, crayfish).

🧪 Formulation Notes

Glucosamine and Chondroitin support joint and cartilage health.

No added Sugar, Yeast, Preservatives, Artificial Flavors or Colors.

Contains shellfish (shrimp, crab, lobster, crayfish).

Gluten free

Additional Information

Individual results may vary.

Store at room temperature.

Double strength

Joint Health Support

Guaranteed quality Laboratory tested

Gluten free

Product Details

UPC / SKU 7 40985 22787 9

DSLD Entry Date 2019-09-24

Product Type Other Combinations

Form Capsule

Brand 21st Century

DSLD ID 206553

Data Updated 2026-04-11

Research Evidence

39 Research Sources

50 Avg Quality Score

20 Rct

9 Meta Analysis

4 Clinical Trial

3 Systematic Review

1 Regulatory Source

1 Openfda Safety

B Interventions for the management of temporomandibular joint osteoarthritis

Systematic Review The Cochrane database of systematic reviews 2012

PubMed DOI Cochrane

B Glucosamine therapy for treating osteoarthritis

Meta Analysis The Cochrane database of systematic reviews 2005

PubMed Cochrane

B Chondroitin for osteoarthritis

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI Cochrane

B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis

Meta Analysis Archives of orthopaedic and trauma surgery 2023

PubMed DOI

B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis

Rct The New England journal of medicine 2006

PubMed

B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review

Systematic Review International journal of molecular sciences 2023

PubMed DOI

B Scientific Opinion on glucosamine and joint health

Regulatory Source EFSA Journal 2009

DOI

B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis

Meta Analysis Computational and mathematical methods in medicine 2022

PubMed DOI

B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib

Rct Annals of the rheumatic diseases 2016

PubMed DOI

B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials

Meta Analysis Journal of orthopaedic surgery and research 2018

PubMed DOI

View all evidence for Glucosamine →