Home/ Supplements/ Niacin/ Niacinamide 500 mg

Niacinamide 500 mg

product on market Tablet or Pill Rugby Safety: 60/100
60/100

Review before taking

  • Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Niacin is used to support cholesterol levels and skin health, though evidence for general supplementation is moderate. Due to a lower safety score, users should be aware of potential side effects such as flushing or liver enzyme elevations. Consult a professional regarding appropriate dosing.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This product received a low safety score because the amount of Niacin is over 14 times higher than the recommended upper limit for daily intake.

Label

Product Label

Label for Niacinamide 500 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

500 mg (2500% DV)
Exceeds UL by 14.3× (UL: 35 mg) 196 studies (A:5, B:63)

Other Ingredients

Microcrystalline Cellulose Lactose Stearic Acid Magnesium Silicate Croscarmellose Sodium Silica
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Info

Product Information

Directions for Use

Directions: Adults only: One tablet daily, as a dietary supplement, or as directed by a physician.

Warnings & Precautions

Tamper resistant - Do not use if imprinted safety seal under cap is broken or missing

Contains milk.

Warnings: Do not use this product if you have a known sensitivity or allergy to niacinamide.

Use only under the advice and supervision of a physician if you have any of the following conditions: gallbladder disease or a history of jaundice or liver disease, diabetes, gout or peptic ulcer. Abnormal liver function tests have been reported in persons taking daily doses of 500 mg or more of niacinamide.

Keep out of reach of children.

Formulation Notes

Contains milk.

Warnings: Do not use this product if you have a known sensitivity or allergy to niacinamide.

Free of starch, sodium, soy, gluten, preservatives, yeast, corn, artificial colors and flavors.

Additional Information

To preserve quality and freshness, keep bottle tightly closed. Store between 15(0) - 30(0)C (59(0) - 86(0)F)

Rev. 10/16 R-29 6655-10-16 Re-order No. 370207

120

Metadata

Product Details

UPC / SKU0 05364 06901 4
DSLD Entry Date2019-04-25
Product TypeVitamin
FormTablet or Pill
BrandRugby
DSLD ID200813
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
View all evidence for Niacin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.