🟢 90/100

This product looks safe

  • Niacin: 100mg is 2.9× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

Melatonin is supported by strong evidence for managing sleep onset, while magnesium and vitamin B6 contribute to relaxation and neurotransmitter synthesis. Niacin supports general metabolic function. Overall evidence coverage for this specific combination is limited, though the individual components are generally well-tolerated.

AI-generated summary based on research evidence. Not medical advice.

Product Label

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Safety Alerts

⚠️ Niacin: 100mg is 2.9× the Tolerable Upper Intake Level (35mg)

Label Data

1 Tablet(s) Serving Size
Other Combinations Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

100 mg (500% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 2.9× (UL: 35 mg) 📚 196 studies (Tier A: 5, B: 63)
RDA 14mg This product: 100mg UL 35mg
5 mg (250% DV)
📊 3.8× RDA — above typical dose (UL: 100 mg) 📚 114 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 5mg UL 100mg
40 mg (10% DV)
✅ Within RDA (0.1× RDA of 420 mg) 📚 316 studies (Tier A: 8, B: 159)
RDA 420mg This product: 40mg UL 350mg
1 mg
📊 Market median: 3.0mg (984 products) 📚 240 studies (Tier A: 2, B: 109)
This product: 1mg UL 10mg

Other Ingredients

Calcium Carbonate Cellulose Stearic Acid Magnesium Stearate Vegetable Coating

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (86% of products) Nutrient (7% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

SUGGESTED USAGE: As a dietary supplement, take one tablet about 1 hour before bedtime with juice or water. Consider taking this product in combination with NOW(R) True Calm(TM) and 5-HTP.

⚠️ Warnings & Precautions

Caution: If you are under medical supervision seek the advice of your physician or health care professional prior to use.

Individuals with auto-immune conditions, depressive disorders, those taking sedatives or corticosteroid drugs, pregnant or lactating women, should consult their physician prior to use.

This product may cause drowsiness. Do not operate a vehicle or heavy machinery following consumption of melatonin.

Keep out of reach of children.

Do Not Eat Freshness Packet. Keep in Bottle.

🧪 Formulation Notes

Vegetarian Formula

Contains no sugar, salt, starch, yeast, wheat, gluten, corn, soy, milk, egg, shellfish or preservatives.

Vegetarian/Vegan Product.

Additional Information

Store in a cool, dry place.

Please Recycle.

Made in the U.S.A.

ACTUAL SIZE

HELPS REGULATE SLEEP CYCLE* • Two Stage Release • With Co-Factor Nutrients

GMP QUALITY ASSURED

Research indicates that Melatonin may be associated with the regulation of sleep/wake cycles. Melatonin is a potent antioxidant that defends against free radicals and helps to support glutathione activity in the neural tissue.*

CODE 3263 V2

Product Details

UPC / SKU 7 33739 03263 8
DSLD Entry Date 2012-10-25
Product Type Other Combinations
Form Tablet or Pill
Brand NOW
DSLD ID 14830
Data Updated 2026-04-11

Research Evidence

291 Research Sources
55 Avg Quality Score
129 Meta Analysis
93 Systematic Review
51 Rct
11 Clinical Trial
2 Other
2 Regulatory Source
1 Openfda Safety
A Interventions for preventing delirium in hospitalised non-ICU patients
Meta Analysis The Cochrane database of systematic reviews 2016
A Melatonin for preoperative and postoperative anxiety in adults
Meta Analysis The Cochrane database of systematic reviews 2020
A Effect of melatonin on quality of life and symptoms in patients with cancer: a systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ open 2022
B Pharmacological interventions for prevention of weight gain in people with schizophrenia
Meta Analysis The Cochrane database of systematic reviews 2022
B Melatonin for pre- and postoperative anxiety in adults
Meta Analysis The Cochrane database of systematic reviews 2015
B Prevention of depression in adults with long-term physical conditions
Meta Analysis The Cochrane database of systematic reviews 2021
B Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis
Systematic Review Lancet (London, England) 2022
B Does melatonin administration reduce the incidence of postoperative delirium in adults? Systematic review and meta-analysis
Meta Analysis BMJ open 2023
B Second-generation antidepressants for preventing seasonal affective disorder in adults
Meta Analysis The Cochrane database of systematic reviews 2015
B Interventions for preventing type 2 diabetes in adults with mental disorders in low- and middle-income countries
Meta Analysis The Cochrane database of systematic reviews 2021
View all evidence for Melatonin →

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